Proguss toward an HIV vaccine

被引：92

作者：

Letvin, NL ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Boston, MA 02115 USA

来源：

ANNUAL REVIEW OF MEDICINE | 2005年 / 56卷

关键词：

cytotoxic T lymphocytes; nonhuman primate models; HIV immunity; DNA vaccines; live recombinant vectors;

D O I：

10.1146/annurev.med.54.101601.152349

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The development of an HIV vaccine is proving to be an unprecedented challenge. The difficulty in creating this vaccine arises from the enormous genetic variation of the virus and the unusual importance of cytotoxic T lymphocytes (CTL) in controlling its spread. Whereas traditional vaccine strategies are unlikely to confer safe and effective HIV protection, novel strategies for eliciting CTL have provided substantial clinical benefits in nonhuman primate model systems. These vaccine strategies, including plasmid DNA and live recombinant vectors, are currently being evaluated in human clinical trials.

引用

页码：213 / 223

页数：11

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