Prevalence and impact of rhinitis in asthma. SACRA, a cross-sectional nation-wide study in Japan

被引：86

作者：

Ohta, K. ^{[1
]}

Bousquet, P. -J. ^{[2
]}

Aizawa, H. ^{[3
]}

Akiyama, K.

Adachi, M. ^{[5
]}

Ichinose, M. ^{[6
]}

Ebisawa, M. ^{[4
]}

Tamura, G. ^{[7
]}

Nagai, A. ^{[8
]}

Nishima, S. ^{[9
]}

Fukuda, T. ^{[10
]}

Morikawa, A. ^{[11
]}

Okamoto, Y. ^{[12
]}

Kohno, Y. ^{[13
]}

Saito, H. ^{[14
]}

Takenaka, H. ^{[15
]}

Grouse, L. ^{[16
]}

Bousquet, J. ^{[17
,18
]}

机构：

[1] Teikyo Univ, Sch Med, Dept Med, Div Resp Med & Allergol,Itabashi Ku, Tokyo 1738605, Japan

[2] Grp Hosp Univ Caremeau, Dept Biostat Epidemiol Clin Sante Publ & Informat, Nimes, France

[3] Kurume Univ, Sch Med, Dept Med, Div Respirol Neurol & Rheumatol, Fukuoka, Japan

[4] Sagamihara Natl Hosp, Natl Hosp Org, Clin Res Ctr Allergy & Rheumatol, Dept Allergy, Kanagawa, Japan

[5] Showa Univ, Sch Med, Dept Med, Div Respirol & Allergol, Tokyo 142, Japan

[6] Wakayama Med Univ, Sch Med, Dept Internal Med 3, Wakayama, Japan

[7] Airway Inst, Sendai, Miyagi, Japan

[8] Tokyo Womens Univ, Dept Med 1, Tokyo, Japan

[9] Fukuoka Natl Hosp, NHO, Fukuoka, Japan

[10] Dokkyo Univ, Sch Med, Dept Pulm Med & Clin Immunol, Mibu, Tochigi, Japan

[11] Gunma Univ, Kitakanto Allergy Inst, Kibonoie Hosp, Gunma, Japan

[12] Chiba Univ, Grad Sch Med, Dept Otolaryngol Head & Neck Surg, Chiba, Japan

[13] Chiba Univ, Grad Sch Med, Dept Pediat, Chiba, Japan

[14] Natl Res Inst Child Hlth & Dev, Tokyo, Japan

[15] Osaka Med Coll, Dept Otolaryngol, Osaka, Japan

[16] MCR, Seattle, WA USA

[17] Hop Arnaud de Villeneuve, Serv Malad Resp, Montpellier, France

[18] INSERM, CESP Ctr Res Epidemiol & Populat Hlth, Resp & Environm Epidemiol Team, U1018, Villejuif, France

来源：

ALLERGY | 2011年 / 66卷 / 10期

关键词：

Allergic Rhinitis and its Impact on Asthma; asthma; Global Initiative for Asthma; rhinitis; Visual Analog Scale; ALLERGIC RHINITIS; MANAGEMENT; DIAGNOSIS; SEVERITY; GA(2)LEN; DISEASE; ECZEMA; RISK;

D O I：

10.1111/j.1398-9995.2011.02676.x

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Background: Asthma and rhinitis are common co-morbidities everywhere in the world but nation-wide studies assessing rhinitis in asthmatics using questionnaires based on guidelines are not available. Objective: To assess the prevalence, classification, and severity of rhinitis using the Allergic Rhinitis and its Impact on Asthma (ARIA) criteria in Japanese patients with diagnosed and treated asthma. Methods: The study was performed from March to August 2009. Patients in physicians' waiting rooms, or physicians themselves, filled out questionnaires on rhinitis and asthma based on ARIA and Global Initiative for Asthma (GINA) diagnostic guides. The patients answered questions on the severity of the diseases and a Visual Analog Scale. Their physicians made the diagnosis of rhinitis. Results: In this study, 1910 physicians enrolled 29 518 asthmatics; 15 051 (51.0%) questionnaires were administered by physician, and 26 680 (90.4%) patients were evaluable. Self-and physician-administered questionnaires gave similar results. Rhinitis was diagnosed in 68.5% of patients with self-administered questionnaires and 66.2% with physician-administered questionnaires. In this study, 994 (7.6%) patients with self-administered and 561 (5.2%) patients with physician-administered questionnaires indicated rhinitis symptoms on the questionnaires without a physician's diagnosis of rhinitis. Most patients with the physician's diagnosis of rhinitis had moderate/severe rhinitis. Asthma control was significantly impaired in patients with a physician's diagnosis of rhinitis for all GINA clinical criteria except exacerbations. There were significantly more patients with uncontrolled asthma as defined by GINA in those with a physician's diagnosis of rhinitis (25.4% and 29.7%) by comparison with those without rhinitis (18.0% and 22.8%). Conclusion: Rhinitis is common in asthma and impairs asthma control.

引用

页码：1287 / 1295

页数：9

共 31 条

[1] Prevalence of symptoms of asthma, rhinitis and eczema in 13-to 14-year-old children in Africa: the International Study of Asthma and Allergies in Childhood Phase III [J].

Ait-Khaled, N. ;

Odhiambo, J. ;

Pearce, N. ;

Adjoh, K. S. ;

Maesano, I. A. ;

Benhabyles, B. ;

Bouhayad, Z. ;

Bahati, E. ;

Camara, L. ;

Catteau, C. ;

El Sony, A. ;

Esamai, F. O. ;

Hypolite, I. E. ;

Melaku, K. ;

Musa, O. A. ;

Ng'ang'a, L. ;

Onadeko, B. O. ;

Saad, O. ;

Jerray, M. ;

Kayembe, J. M. ;

Koffi, N. B. ;

Khaldi, F. ;

Kuaban, C. ;

Voyi, K. ;

M'Boussa, J. ;

Sow, O. ;

Tidjani, O. ;

Zar, H. J. .

ALLERGY, 2007, 62 (03) :247-258

[2] Global strategy for asthma management and prevention: GINA executive summary [J].

Bateman, E. D. ;

Hurd, S. S. ;

Barnes, P. J. ;

Bousquet, J. ;

Drazen, J. M. ;

FitzGerald, M. ;

Gibson, P. ;

Ohta, K. ;

O'Byrne, P. ;

Pedersen, S. E. ;

Pizzichini, E. ;

Sullivan, S. D. ;

Wenzel, S. E. ;

Zar, H. J. .

EUROPEAN RESPIRATORY JOURNAL, 2008, 31 (01) :143-178

[3] Important research questions in allergy and related diseases:: nonallergic rhinitis:: a GA2LEN paper [J].

Bousquet, J. ;

Fokkens, W. ;

Burney, P. ;

Durham, S. R. ;

Bachert, C. ;

Akdis, C. A. ;

Canonica, G. W. ;

Dahlen, S. -E. ;

Zuberbier, T. ;

Bieber, T. ;

Bonini, S. ;

Bousquet, P. J. ;

Brozek, J. L. ;

Cardell, L. -O. ;

Crameri, R. ;

Custovic, A. ;

Demoly, P. ;

van Wijk, R. G. ;

Gjomarkaj, M. ;

Holland, C. ;

Howarth, P. ;

Humbert, M. ;

Johnston, S. L. ;

Kauffmann, F. ;

Kowalski, M. L. ;

Lambrecht, B. ;

Lehmann, S. ;

Leynaert, B. ;

Lodrup-Carlsen, K. ;

Mullol, J. ;

Niggemann, B. ;

Nizankowska-Mogilnicka, E. ;

Papadopoulos, N. ;

Passalacqua, G. ;

Schuenemann, H. J. ;

Simon, H. -U. ;

Todo-Bom, A. ;

Toskala, E. ;

Valenta, R. ;

Wickman, M. ;

Zock, J. P. .

ALLERGY, 2008, 63 (07) :842-853

[4] Allergic rhinitis and its impact on asthma (ARIA) 2008 update (in collaboration with the World Health Organization, GA2LEN and AllerGen) [J].

Bousquet, J. ;

Khaltaev, N. ;

Cruz, A. A. ;

Denburg, J. ;

Fokkens, W. J. ;

Togias, A. ;

Zuberbier, T. ;

Baena-Cagnani, C. E. ;

Canonica, G. W. ;

van Weel, C. ;

Agache, I. ;

Ait-Khaled, N. ;

Bachert, C. ;

Blaiss, M. S. ;

Bonini, S. ;

Boulet, L. -P. ;

Bousquet, P. -J. ;

Camargos, P. ;

Carlsen, K. -H. ;

Chen, Y. ;

Custovic, A. ;

Dahl, R. ;

Demoly, P. ;

Douagui, H. ;

Durham, S. R. ;

van Wijk, R. Gerth ;

Kalayci, O. ;

Kaliner, M. A. ;

Kim, Y. -Y. ;

Kowalski, M. L. ;

Kuna, P. ;

Le, L. T. T. ;

Lemiere, C. ;

Li, J. ;

Lockey, R. F. ;

Mavale-Manuel, S. ;

Meltzer, E. O. ;

Mohammad, Y. ;

Mullol, J. ;

Naclerio, R. ;

Hehir, R. E. O. ;

Ohta, K. ;

Ouedraogo, S. ;

Palkonen, S. ;

Papadopoulos, N. ;

Passalacqua, G. ;

Pawankar, R. ;

Popov, T. A. ;

Rabe, K. F. ;

Rosado-Pinto, J. .

ALLERGY, 2008, 63 :8-+

[5] Increased risk of asthma attacks and emergency visits among asthma patients with allergic rhinitis: a subgroup analysis of the improving asthma control trial [J].

Bousquet, J ;

Gaugris, S ;

Kocevar, VS ;

Zhang, Q ;

Yin, DD ;

Polos, PG ;

Bjermer, L .

CLINICAL AND EXPERIMENTAL ALLERGY, 2005, 35 (06) :723-727

[6] Allergic rhinitis and its impact on asthma [J].

Bousquet, J ;

van Cauwenberge, P ;

Khaltaev, N ;

Ait-Khaled, N ;

Annesi-Maesano, I ;

Bachert, C ;

Baena-Cagnani, C ;

Bateman, E ;

Bonini, S ;

Canonica, GW ;

Carlsen, KH ;

Demoly, P ;

Durham, SR ;

Enarson, D ;

Fokkens, WJ ;

van Wijk, RG ;

Howarth, P ;

Ivanova, NA ;

Kemp, JP ;

Klossek, JM ;

Lockey, RF ;

Lund, V ;

Mackay, I ;

Malling, HJ ;

Meltzer, EO ;

Mygind, N ;

Okunda, M ;

Pawankar, R ;

Price, D ;

Scadding, GK ;

Simons, FER ;

Szczeklik, A ;

Valovirta, E ;

Vignola, AM ;

Wang, DY ;

Warner, JO ;

Weiss, KB .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2001, 108 (05) :S147-S334

[7] Visual analog scales can assess the severity of rhinitis graded according to ARIA guidelines [J].

Bousquet, P. J. ;

Combescure, C. ;

Neukirch, F. ;

Klossek, J. M. ;

Mechin, H. ;

Daures, J. -P. ;

Bousquet, J. .

ALLERGY, 2007, 62 (04) :367-372

[8] Change in visual analog scale score in a pragmatic randomized cluster trial of allergic rhinitis [J].

Bousquet, Philippe-Jean ;

Combescure, Christophe ;

Klossek, Jean-Michel ;

Daures, Jean-Pierre ;

Bousquet, Jean .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2009, 123 (06) :1349-1354

[9] Rhinosinusitis in severe asthma [J].

Bresciani, M ;

Paradis, L ;

Des Roches, A ;

Vernhet, H ;

Vachier, I ;

Godard, P ;

Bousquet, J ;

Chanez, P .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2001, 107 (01) :73-80

[10] Complexities of Diagnosis and Treatment of Allergic Respiratory Disease in the Elderly [J].

Busse, Paula J. ;

Kilaru, Kiran .

DRUGS & AGING, 2009, 26 (01) :1-22

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