Risk-Reducing Options for High-Grade Serous Gynecologic Malignancy in BRCA1/2

被引：6
作者：
Clarfield, Lauren [1 ]
Diamond, Laura [1 ]
Jacobson, Michelle [2 ,3 ,4 ]
机构：
[1] Univ Toronto, Temerty Fac Med, Toronto, ON M5S 1A8, Canada
[2] Univ Toronto, Dept Obstet & Gynecol, Toronto, ON M5G 1E2, Canada
[3] Mt Sinai Hosp, Dept Obstet & Gynecol, Toronto, ON M5T 2Z5, Canada
[4] Womens Coll Hosp, Dept Obstet & Gynecol, Toronto, ON M5S 1B2, Canada
来源：
CURRENT ONCOLOGY | 2022年 / 29卷 / 03期
关键词：
ovarian neoplasms; genes; BRCA; 2; 1; endometrial neoplasms; contraceptives; oral; hysterectomy; salpingo-oophorectomy; breast neoplasms; genetic predisposition to disease; germ-line mutation; DEPOT-MEDROXYPROGESTERONE ACETATE; CONTRALATERAL BREAST-CANCER; ORAL-CONTRACEPTIVE USE; OVARIAN-CANCER; MUTATION CARRIERS; SALPINGO-OOPHORECTOMY; FALLOPIAN-TUBE; UTERINE-CANCER; ENDOMETRIAL CANCER; WOMEN;
D O I：
10.3390/curroncol29030172
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Ovarian cancer (OC) is the leading cause of death among women with gynecologic malignancy. Breast Cancer Susceptibility Gene 1 (BRCA 1) and Breast Cancer Susceptibility Gene 2 (BRCA 2) germline mutations confer an estimated 20 to 40 times increased risk of OC when compared to the general population. The majority of BRCA-associated OC is identified in the late stage, and no effective screening method has been proven to reduce mortality. Several pharmacologic and surgical options exist for risk-reduction of gynecologic malignancy in BRCA 1/2 mutation carriers. This review summarizes up-to-date research on pharmacologic risk-reducing interventions, including the oral contraceptive pill, acetylsalicylic acid/nonsteroidal anti inflammatory drugs (ASA/NSAID) therapy, and denosumab, and surgical risk-reducing interventions, including risk-reducing bilateral salpingo-oophorectomy, salpingectomy with delayed oophorectomy, and hysterectomy at the time of risk-reducing bilateral salpingo-oophorectomy.
引用
收藏
页码：2132 / 2140
页数：9
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