Spatial control of cAMP signalling in health and disease

被引：73

作者：

Zaccolo, Manuela ^{[1
]}

机构：

[1] Univ Glasgow, Mol Pharmacol Ctr, Inst Neurosci & Psychol, Glasgow G12 8QQ, Lanark, Scotland

来源：

CURRENT OPINION IN PHARMACOLOGY | 2011年 / 11卷 / 06期

关键词：

PROTEIN-COUPLED RECEPTORS; SOLUBLE ADENYLYL-CYCLASE; KINASE BINDING DOMAIN; RAT CARDIAC MYOCYTES; CYCLIC-AMP; INSULIN-SECRETION; HEART-FAILURE; BETA-CELLS; PHOSPHODIESTERASES; PKA;

D O I：

10.1016/j.coph.2011.09.014

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The cyclic adenosine 3',5'-monophosphate signalling pathway is now recognised to transduce signals in a compartmentalised manner such that individual stimuli only engage a subset of the pathway components that are physically constrained within defined subcellular locales, thus resulting in a precise functional outcome. As we are starting to appreciate the complexity of the spatial organisation and of the temporal regulation of this pathway, it is becoming clear that disruption of local signalling may lead to pathology and that local manipulation of cAMP signals may offer alternative approaches to treat disease.

引用

页码：649 / 655

页数：7

共 55 条

[1] Cyclic AMP Produced inside Mitochondria Regulates Oxidative Phosphorylation [J].

Acin-Perez, Rebeca ;

Salazar, Eric ;

Kamenetsky, Margarita ;

Buck, Jochen ;

Levin, Lonny R. ;

Manfredi, Giovanni .

CELL METABOLISM, 2009, 9 (03) :265-276

[2] Type 2 diabetes, insulin secretion and β-cell mass [J].

Ahrén, B .

CURRENT MOLECULAR MEDICINE, 2005, 5 (03) :275-286

[3] Islet G protein-coupled receptors as potential targets for treatment of type 2 diabetes [J].

Ahren, Bo .

NATURE REVIEWS DRUG DISCOVERY, 2009, 8 (05) :369-385

[4]

AYE TT, 2011, J MOL CELL CARDIOL, DOI DOI 10.1016/LYJMCC.2011.06.003

[5] Dynamic regulation of cAMP synthesis through anchored PKA-Adenylyl cyclase V/VI complexes [J].

Bauman, Andrea L. ;

Soughayer, Joseph ;

Nguyen, Bao T. ;

Willoughby, Debbie ;

Carnegie, Graeme K. ;

Wong, Wei ;

Hoshi, Naoto ;

Langeberg, Lorene K. ;

Cooper, Dermot M. F. ;

Dessauer, Carmen W. ;

Scott, John D. .

MOLECULAR CELL, 2006, 23 (06) :925-931

[6] A-kinase anchoring proteins take shape [J].

Beene, Darren L. ;

Scott, John D. .

CURRENT OPINION IN CELL BIOLOGY, 2007, 19 (02) :192-198

[7] Exocytotic Properties of Human Pancreatic β-cells [J].

Braun, Matthias ;

Ramracheya, Reshma ;

Johnson, Paul R. ;

Rorsman, Patrik .

MECHANISMS OF EXOCYTOSIS, 2009, 1152 :187-193

[8] Persistent cAMP-Signals Triggered by Internalized G-Protein-Coupled Receptors [J].

Calebiro, Davide ;

Nikolaev, Viacheslav O. ;

Gagliani, Maria Cristina ;

de Filippis, Tiziana ;

Dees, Christian ;

Tacchetti, Carlo ;

Persani, Luca ;

Lohse, Martin J. .

PLOS BIOLOGY, 2009, 7 (08)

[9] Cyclic guanosine monophosphate compartmentation in rat cardiac myocytes [J].

Castro, LRV ;

Verde, I ;

Cooper, DMF ;

Fischmeister, R .

CIRCULATION, 2006, 113 (18) :2221-2228

[10] Mutation of an A-kinase-anchoring protein causes long-QT syndrome [J].

Chen, Lei ;

Marquardt, Michelle L. ;

Tester, David J. ;

Sampson, Kevin J. ;

Ackerman, Michael J. ;

Kass, Robert S. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (52) :20990-20995

← 1 2 3 4 5 6 →