The HIV type 1 epidemic in Belarus: Predominance of Eastern European subtype a strains and circulation of subtype B viruses

被引：19
作者：
Lazouskaya, NV
Eremin, VF
Adema, KW
Gasich, EL
Baan, E
Lukashov, VV
机构：
[1] Univ Amsterdam, Acad Med Ctr, Dept Human Retrovirol, NL-1105 AZ Amsterdam, Netherlands
[2] Inst Epidemiol & Microbiol, Dept Clin Virol, Minsk 220014, BELARUS
[3] DI Ivanovskii Inst Virol, Lab Immunochem, Moscow 123098, Russia
来源：
AIDS RESEARCH AND HUMAN RETROVIRUSES | 2005年 / 21卷 / 09期
关键词：
D O I：
10.1089/aid.2005.21.830
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
To study the molecular epidemiology of HIV-1 in Belarus, where the rapid spread of HIV-1 has been registered since 1996, we obtained HIV-1 sequences from 30 individuals living in five cities in both the main geographic areas of the epidemic (Gomel and Minsk regions) and territories where spreading of the epidemic remains limited (Grodno region). Analysis of env V3 and gag p17/p24 sequences demonstrated that infections in all 12 injecting drug users and 14 of 18 individuals infected through sexual contacts were caused by subtype A viruses that are specific for the epidemic in the former Soviet Union (IDU-A viruses), while the remaining four infections were caused by phylogenetically unrelated to each other subtype B viruses. Extrapolation of these results to the total population of HIV-1-infected individuals in Belarus allowed us to estimate that IDU-A viruses account for nearly 95% of HIV-1 infections in Belarus.
引用
收藏
页码：830 / 833
页数：4
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