DISTRIBUTION, BIOLOGICAL ACTIVITIES, SYNTHESIS, AND PURIFICATION METHODS FOR PODOPHYLLOTOXIN AND ITS DERIVATIVES

被引：4
作者：
Medrado, Hector Hugo S. [1 ]
David, Jorge M. [1 ]
David, Juceni P. [2 ]
Brandao, Hugo N. [3 ]
机构：
[1] Univ Fed Bahia, Inst Quim, BR-40170280 Salvador, BA, Brazil
[2] Univ Fed Bahia, Fac Farm, BR-40170280 Salvador, BA, Brazil
[3] Univ Estadual Feira de Santana, Dept Saude, BR-44036900 Feira De Santana, BA, Brazil
来源：
QUIMICA NOVA | 2015年 / 38卷 / 02期
关键词：
podophyllotoxin; etoposide; Etopophos; teniposide; anticancer; NATURAL-PRODUCTS; LIGNANS; BIOSYNTHESIS; PHARMACOLOGY; CHEMISTRY; ETOPOSIDE; ROUTE;
D O I：
10.5935/0100-4042.20140294
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Podophyllotoxin is the most studied lignan because of its use as an antimitotic agent and because it is a precursor of pharmacologically active derivatives. This review describes the anticancer activities of podophyllotoxin and the different processes that have been developed for its extraction and purification from Podophyllum spp. In addition, the synthesis routes of this compound and the development of three semi-synthetic procedures to obtain etoposide, teniposide, and Etopophos are detailed.
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收藏
页码：243 / 258
页数：16
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