Potential Management of Circulating Tumor DNA as a Biomarker in Triple-Negative Breast Cancer

被引：30

作者：

Shang, Mao ^{[1
,2
]}

Chang, Chunxiao ^{[3
]}

Pei, Yanqing ^{[4
]}

Guan, Yin ^{[5
]}

Chang, Jin ^{[6
]}

Li, HuiHui ^{[3
]}

机构：

[1] Univ Jinan, Shandong Acad Med Sci, Sch Med & Life Sci, Jinan, Shandong, Peoples R China

[2] Shandong Univ, Shandong Canc Hosp, Shandong Acad Med Sci, Dept Radiat Oncol, Jinan 250117, Shandong, Peoples R China

[3] Shandong Univ, Shandong Canc Hosp, Shandong Acad Med Sci, Dept Med Oncol, Jinan 250117, Shandong, Peoples R China

[4] Shandong Univ, Shandong Canc Hosp, Shandong Acad Med Sci, Dept Qual Management Off, Jinan 250117, Shandong, Peoples R China

[5] Beijing Chao Yang Hosp, Dept Med Oncol, Beijing, Peoples R China

[6] Taishan Med Univ, Affiliated Hosp, Dept Oncol, Tai An, Shandong, Peoples R China

来源：

JOURNAL OF CANCER | 2018年 / 9卷 / 24期

基金：

中国国家自然科学基金;

关键词：

triple-negative breast cancer; circulating tumor DNA; liquid biopsy; CELL-FREE DNA; NEOADJUVANT CHEMOTHERAPY; PROGNOSTIC-SIGNIFICANCE; PLASMA; METHYLATION; THERAPY; HETEROGENEITY; EXPRESSION; SURVIVAL; MUTATION;

D O I：

10.7150/jca.28458

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

As a specific subtype of breast cancer, Triple-negative breast cancer (TNBC) is associated with worse prognosis and higher tumor aggressiveness than HER2-amplified or hormone receptor positive breast cancers. Circulating tumor DNA (ctDNA), as a non-invasive "liquid biopsy", is an emerging original blood-based biomarker for early breast cancer diagnosis, monitoring treatment response, and determining prognosis. In TNBC patients, ctDNA has an inherent tendency to characterize tumor heterogeneity and metastasis-specific mutations providing a key alternative to tumor tissue profiling. Several studies have already demonstrated the potential of ctDNA in TNBC patients from early to advanced stages of the disease including diagnosis, therapy decisions and assessment of prognosis. This review provides a critical brief summary of the evidence that gives credence to the utility of ctDNA as a biomarker for its role into clinical management in TNBC.

引用

页码：4627 / 4634

页数：8

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