Molecular Inflammation as an Underlying Mechanism of the Aging Process and Age-related Diseases

被引：183

作者：

Chung, H. Y. ^{[1
,2
]}

Lee, E. K. ^{[1
,2
]}

Choi, Y. J. ^{[1
,2
]}

Kim, J. M. ^{[1
,2
]}

Kim, D. H. ^{[3
]}

Zou, Y. ^{[4
]}

Kim, C. H. ^{[5
]}

Lee, J. ^{[1
,2
]}

Kim, H. S. ^{[1
,2
]}

Kim, N. D. ^{[1
,2
]}

Jung, J. H. ^{[1
,2
]}

Yu, B. P. ^{[6
]}

机构：

[1] Pusan Natl Univ, Mol Inflammat Res Ctr Aging Intervent, Pusan 609735, South Korea

[2] Pusan Natl Univ, Coll Pharm, Dept Pharm, Pusan 609735, South Korea

[3] Univ Pittsburgh, Childrens Hosp Pittsburgh, Dept Pediat, Sch Med,Rangos Res Ctr, Pittsburgh, PA 15224 USA

[4] Stanford Univ, Sch Med, Dept Neurol & Neurol Sci, Stanford, CA 94305 USA

[5] Theragen Bio Inst AICT, Div Genome Anal, Suwon 443270, South Korea

[6] Univ Texas Hlth Sci Ctr San Antonio, Dept Physiol, San Antonio, TX 78229 USA

来源：

JOURNAL OF DENTAL RESEARCH | 2011年 / 90卷 / 07期

关键词：

inflammation; oxidative stress; cytokines; gingivitis; aging; age-related diseases; NF-KAPPA-B; NECROSIS-FACTOR-ALPHA; FORKHEAD TRANSCRIPTION FACTORS; ACTIVATED RECEPTORS PPARS; CALORIE RESTRICTION; OXIDATIVE STRESS; GENE-EXPRESSION; INSULIN-RESISTANCE; REACTIVE OXYGEN; PERIODONTAL INFLAMMATION;

D O I：

10.1177/0022034510387794

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

Aging is a biological process characterized by time-dependent functional declines that are influenced by changes in redox status and by oxidative stress-induced inflammatory reactions. An organism's pro-inflammatory status may underlie the aging process and age-related diseases. In this review, we explore the molecular basis of low-grade, unresolved, subclinical inflammation as a major risk factor for exacerbating the aging process and age-related diseases. We focus on the redox-sensitive transcription factors, NF-kappa B and FOXO, which play essential roles in the expression of pro-inflammatory mediators and anti-oxidant enzymes, respectively. Major players in molecular inflammation are discussed with respect to the age-related up-regulation of pro-inflammatory cytokines and adhesion molecules, cyclooxygenase-2, lipoxygenase, and inducible nitric oxide synthase. The molecular inflammation hypothesis proposed by our laboratory is briefly described to give further molecular insights into the intricate interplay among redox balance, pro-inflammatory gene activation, and chronic age-related inflammatory diseases. The final section discusses calorie restriction as an aging-retarding intervention that also exhibits extraordinarily effective anti-inflammatory activity by modulating GSH redox, NF-kappa B, SIRT1, PPARs, and FOXOs.

引用

页码：830 / 840

页数：11

共 144 条

[11] Elevated levels of tumor necrosis factor alpha and mortality in centenarians [J].