Inhibitory motor control in children with attention-deficit/hyperactivity disorder: Event-related potentials in the stop-signal paradigm

被引:149
作者
Dimoska, A
Johnstone, SJ [1 ]
Barry, RJ
Clarke, AR
机构
[1] Univ Wollongong, Brain & Behav Res Inst, Wollongong, NSW 2522, Australia
[2] Univ Wollongong, Dept Psychol, Wollongong, NSW 2522, Australia
关键词
inhibition; attention-deficit/hyperactivity disorder; ADHD; event-related potentials; stop-signal paradigm;
D O I
10.1016/S0006-3223(03)00703-0
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Background: The aim of the study was to investigate the inhibitory control of an ongoing motor response and to identify underlying neural deficiencies, manifested in event-related potentials, that cause poorer inhibitory performance in children with attention-deficit/hyperactivity disorder. Methods: A stop-signal paradigm with a primary visual task and auditory stop signal was used to compare performance in 13 children with attention-deficit/hyperactivity disorder and 13 control children, while event-related potentials were recorded simultaneously: Results: Children with attention-deficit/hyperactivity disorder showed poorer inhibitory performance through a slower inhibitory process. Inhibitory processing of auditory stop signals was marked by a frontal N2 component that was reduced in the attention-deficit/hyperactivity disorder group relative to controls. A central positive component (P3) was associated with the success of inhibiting a response, but there were no group differences in its amplitude or latency. Conclusions: Findings support the hypothesis of deficient inhibitory control in children with attention-deficit/hyperactivity disorder. Slower inhibitory processing appears to be due to a specific neural deficiency that manifests in the processing of the stop signal as attenuated negativity in the N2 latency range.
引用
收藏
页码:1345 / 1354
页数:10
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