Nanosized Contrast Agents in Ultrasound Molecular Imaging

被引：18

作者：

Zeng, Fengyi ^{[1
,2
,3
]}

Du, Meng ^{[1
,2
]}

Chen, Zhiyi ^{[1
,2
]}

机构：

[1] Univ South China, Hengyang Med Sch, Affiliated Hosp 1, Med Imaging Ctr, Hengyang, Peoples R China

[2] Univ South China, Hengyang Med Sch, Inst Med Imaging, Hengyang, Peoples R China

[3] Guangzhou Med Univ, Lab Ultrasound Mol Imaging, Affiliated Hosp 3, Guangzhou, Peoples R China

来源：

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY | 2021年 / 9卷

基金：

国家重点研发计划; 中国国家自然科学基金;

关键词：

nanosized; contrast agents; ultrasound molecular imaging; nanobubbles; gas vesicles; GAS VESICLE; NANOBUBBLES; MICROBUBBLES; INFLAMMATION; DELIVERY; TUMORS; GENE; QUANTIFICATION; COMPLEMENT; ADHERENCE;

D O I：

10.3389/fbioe.2021.758084

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Applying nanosized ultrasound contrast agents (nUCAs) in molecular imaging has received considerable attention. nUCAs have been instrumental in ultrasound molecular imaging to enhance sensitivity, identification, and quantification. nUCAs can achieve high performance in molecular imaging, which was influenced by synthetic formulations and size. This review presents an overview of nUCAs from different synthetic formulations with a discussion on imaging and detection technology. Then we also review the progress of nUCAs in preclinical application and highlight the recent challenges of nUCAs.

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