Reflective Diffraction Gratings From Hydrogels as Biochemical Sensors

被引：18

作者：

Chang, Chun-Li ^{[1
,2
]}

Ding, Zhenwen ^{[2
,3
]}

Patchigolla, Venkata N. L. R. ^{[2
]}

Ziaie, Babak ^{[2
,4
]}

Savran, Cagri A. ^{[1
,2
]}

机构：

[1] Purdue Univ, Sch Mech Engn, Weldon Sch Biomed Engn, W Lafayette, IN 47907 USA

[2] Purdue Univ, Birck Nanotechnol Ctr, W Lafayette, IN 47907 USA

[3] Purdue Univ, Dept Phys, W Lafayette, IN 47907 USA

[4] Purdue Univ, Sch Elect & Comp Engn, W Lafayette, IN 47907 USA

来源：

IEEE SENSORS JOURNAL | 2012年 / 12卷 / 07期

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

Biochemical sensors; diffraction; gratings; smart hydrogels; GLUCOSE-OXIDASE; PH; CANTILEVER;

D O I：

10.1109/JSEN.2012.2189382

中图分类号：

TM [电工技术]; TN [电子技术、通信技术];

学科分类号：

0808 ; 0809 ;

摘要：

We report reflective diffraction gratings made from smart hydrogels for ultrasensitive biochemical detection. As an example for a stimuli-responsive hydrogel, we chose a pH-sensitive hydrogel to construct diffraction gratings that swell/shrink reversibly due to changes in pH. Interferometric analysis of the grating enabled detection of the hydrogel's motions with nanoscale precision and resulted in a resolution of 6 x 10(-4) pH units. The developed system is remarkably simple both to fabricate and operate, and yet extremely sensitive. Moreover, the concept of the reflective hydrogel grating is generic and can be applied detection of a wide range of other stimuli.

引用

页码：2374 / 2379

页数：6

共 26 条

[1] Micromechanical cantilever as an ultrasensitive pH microsensor [J].

Bashir, R ;

Hilt, JZ ;

Elibol, O ;

Gupta, A ;

Peppas, NA .

APPLIED PHYSICS LETTERS, 2002, 81 (16) :3091-3093

[2]

Chang C. L., 2007, APPL PHYS LETT, V90

[3] Diffractometric Biochemical Sensing with Smart Hydrogels [J].

Chang, Chun-Li ;

Ding, Zhenwen ;

Patchigolla, Venkata N. L. R. ;

Ziaie, Babak ;

Savran, Cagri A. .

2010 IEEE SENSORS, 2010, :1617-1621

[4] Microgels: Old materials with new applications [J].

Das, Mallika ;

Zhang, Hong ;

Kumacheva, Eugenia .

ANNUAL REVIEW OF MATERIALS RESEARCH, 2006, 36 :117-142

[5] A miniaturized carbon dioxide gas sensor based on sensing of pH-sensitive hydrogel swelling with a pressure sensor [J].

Herber, S ;

Bomer, J ;

Olthuis, W ;

Bergveld, P ;

van den Berg, A .

BIOMEDICAL MICRODEVICES, 2005, 7 (03) :197-204

[6] Ultrasensitive biomems sensors based on microcantilevers patterned with environmentally responsive hydrogels [J].

Hilt, JZ ;

Gupta, AK ;

Bashir, R ;

Peppas, NA .

BIOMEDICAL MICRODEVICES, 2003, 5 (03) :177-184

[7] Review on state-of-the-art in polymer based pH sensors [J].

Korostynska, Olga ;

Arshak, Khalil ;

Gill, Edric ;

Arshak, Arousian .

SENSORS, 2007, 7 (12) :3027-3042

[8] Measurement of pH and dissolved oxygen within cell culture media using a hydrogel microarray sensor [J].

Lee, Seungjoon ;

They, Bennett L. ;

Cote, Gerard L. ;

Pishko, Michael V. .

SENSORS AND ACTUATORS B-CHEMICAL, 2008, 128 (02) :388-398

[9] Integration of hydrogels with hard and soft microstructures [J].

Lei, Ming ;

Ziaie, Babak ;

Nuxoll, Eric ;

Ivan, Kristof ;

Noszticzius, Zoltan ;

Siegel, Ronald A. .

JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY, 2007, 7 (03) :780-789

[10] Differential selection pressure exerted on HIV by CTL targeting identical epitopes but restricted by distinct HLA alleles from the same HLA supertype [J].

Leslie, Alasdair ;

Price, David A. ;

Mkhize, Pamela ;

Bishop, Karen ;

Rathod, Almas ;

Day, Cheryl ;

Crawford, Hayley ;

Honeyborne, Isobella ;

Asher, Tedi E. ;

Luzzi, Graz ;

Edwards, Anne ;

Rosseau, Christine M. ;

Mullins, James I. ;

Tudor-Williams, Gareth ;

Novelli, Vas ;

Brander, Christian ;

Douek, Daniel C. ;

Kiepiela, Photini ;

Walker, Bruce D. ;

Goulder, Philip J. R. .

JOURNAL OF IMMUNOLOGY, 2006, 177 (07) :4699-4708

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