Solvent dependency of the yield of an N-monosubstituted diaziridine: a GC-MS study

被引：2
|
作者：
Billing, Peter [1 ]
Brinker, Udo H. [1 ]
机构：
[1] Univ Vienna, Inst Organ Chem, A-1090 Vienna, Austria
来源：
TETRAHEDRON LETTERS | 2012年 / 53卷 / 23期
关键词：
Diaziridines; Solvent parameters; GC-MS; Optimization; CYCLISCHE DIAZOVERBINDUNGEN; SPIRODIAZIRINES; INHIBITORS;
D O I：
10.1016/j.tetlet.2012.03.105
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Due to the growing importance of diaziridines in the drug design and the increasing popularity of diazirines as carbene precursors, the solvent influence on the yield of an N-monosubstituted diaziridine has been studied. It was observed that data points within every solvent class are clustering and the yield in general is the highest in apolar aprotic solvents. (C) 2012 Elsevier Ltd. All rights reserved.
引用
收藏
页码：2822 / 2824
页数：3
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