Effect of Administration of Haloperidol on the Developing Liver of the Chick Embryo

Most of drugs were metabolized and extruded by both the liver and the kidney. The liver is the first to showing the manifestations of the drug toxicity. The aim of this work was done to compare the effect of administration of the haloperidol drug at (Zero-day) before incubation and at the (5-day) first week of incubation, to get an idea about the extent of the teratogenic effect of this drug on the developing liver. So that morphological and histological studies were done on the liver of 8- and 16-days old chick embryos treated with (0.25 mg\ egg) of haloperidol on the (zero and 5-th days) of incubation. Haloperidol induced retardation of growth of the developing liver of 8-day treated chick embryo. The sign of retardation was investigated in the treated liver of chick embryos which injection at the (zero day) more than which injected at (5-th days) of incubation. The toxic effects of the drug was seen also more at 16-days treated chick embryos. And the drug induced hepatic degeneration at both 8- and 16-days treated liver with focal areas of necrosis. The conclusion from this study was the haloperidol drug has dangerous effects on tissues for this study point, and with powerful toxicity on the cells, because the drug stay for long time in the tissues specially brain and liver. and the effect induced by the drug depend on time of administration