Transgenic and knockout mice in the study of neurodegenerative diseases

被引：33
作者：
Aguzzi, A
Brandner, S
Marino, S
Steinbach, JP
机构：
[1] Institute of Neuropathology, Department of Pathology, CH-8091 Zürich
来源：
JOURNAL OF MOLECULAR MEDICINE-JMM | 1996年 / 74卷 / 03期
关键词：
neurodegeneration; transgenic mouse; prions; spumavirinae; Alzheimer's disease; amyotrophic lateral sclerosis;
D O I：
10.1007/BF01575443
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Accurate animal models are essential for detailed analysis of the mechanisms underlying human neurodegenerative diseases. In addition, they can offer useful paradigms for the development and evaluation of new therapeutic strategies. We review the most popular techniques for modification of the mammalian genome in vivo, and provide a critical evaluation of the available transgenic mouse models for several neurological condition of humans, including prion diseases, human retroviral diseases, Alzheimer's disease, and motor neuron diseases.
引用
收藏
页码：111 / 126
页数：16
相关论文
共 50 条
  • [21] Editorial: Drosophila as a model to study neurodegenerative diseases
    Liguori, Francesco
    Pandey, Udai Bhan
    Digilio, Filomena Anna
    FRONTIERS IN NEUROSCIENCE, 2023, 17
  • [22] Drosophila melanogaster as a model to study autophagy in neurodegenerative diseases induced by proteinopathies
    Santarelli, Stefania
    Londero, Chiara
    Soldano, Alessia
    Candelaresi, Carlotta
    Todeschini, Leonardo
    Vernizzi, Luisa
    Bellosta, Paola
    FRONTIERS IN NEUROSCIENCE, 2023, 17
  • [23] In Vivo NMR Studies of Neurodegenerative Diseases in Transgenic and Rodent Models
    In-Young Choi
    Sang-Pil Lee
    David N. Guilfoyle
    Joseph A. Helpern
    Neurochemical Research, 2003, 28 : 987 - 1001
  • [24] In vivo NMR studies of neurodegenerative diseases in transgenic and rodent models
    Choi, IY
    Lee, SP
    Guilfoyle, DN
    Helpern, JA
    NEUROCHEMICAL RESEARCH, 2003, 28 (07) : 987 - 1001
  • [25] Iron chelation and neuroprotection in neurodegenerative diseases
    Li, Xuping
    Jankovic, Joseph
    Le, Weidong
    JOURNAL OF NEURAL TRANSMISSION, 2011, 118 (03) : 473 - 477
  • [26] Pyrimidine analogues for the management of neurodegenerative diseases
    Pant, Swati
    Kapri, Anandi
    Nain, Sumitra
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY REPORTS, 2022, 6
  • [27] Recent updates on immunotherapy in neurodegenerative diseases
    Salunkhe, Jotiram
    Ugale, Rajesh
    BRAIN RESEARCH, 2024, 1845
  • [28] The Role of Neurovascular System in Neurodegenerative Diseases
    Ajmal Ahmad
    Vanisha Patel
    Jianfeng Xiao
    Mohammad Moshahid Khan
    Molecular Neurobiology, 2020, 57 : 4373 - 4393
  • [29] Inflammation in neurodegenerative diseases-an update
    Amor, Sandra
    Peferoen, Laura A. N.
    Vogel, Daphne Y. S.
    Breur, Marjolein
    van der Valk, Paul
    Baker, David
    van Noort, Johannes M.
    IMMUNOLOGY, 2014, 142 (02) : 151 - 166
  • [30] TREM2 in Neurodegenerative Diseases
    Jay, Taylor R.
    von Saucken, Victoria E.
    Landreth, Gary E.
    MOLECULAR NEURODEGENERATION, 2017, 12
12345