Transgenic and knockout mice in the study of neurodegenerative diseases

被引：33
作者：
Aguzzi, A
Brandner, S
Marino, S
Steinbach, JP
机构：
[1] Institute of Neuropathology, Department of Pathology, CH-8091 Zürich
来源：
JOURNAL OF MOLECULAR MEDICINE-JMM | 1996年 / 74卷 / 03期
关键词：
neurodegeneration; transgenic mouse; prions; spumavirinae; Alzheimer's disease; amyotrophic lateral sclerosis;
D O I：
10.1007/BF01575443
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Accurate animal models are essential for detailed analysis of the mechanisms underlying human neurodegenerative diseases. In addition, they can offer useful paradigms for the development and evaluation of new therapeutic strategies. We review the most popular techniques for modification of the mammalian genome in vivo, and provide a critical evaluation of the available transgenic mouse models for several neurological condition of humans, including prion diseases, human retroviral diseases, Alzheimer's disease, and motor neuron diseases.
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收藏
页码：111 / 126
页数：16
相关论文
共 150 条
[1]  
AGUZZI A, 1992, NEW BIOL, V4, P225
[2]  
AGUZZI A, 1992, BRAIN PATHOL, V2, P61
[3]  
AGUZZI A, 1991, ONCOGENE, V6, P113
[4]   DOES AGENT OF SCRAPIE REPLICATE WITHOUT NUCLEIC ACID [J].
ALPER, T ;
CRAMP, WA ;
HAIG, DA ;
CLARKE, MC .
NATURE, 1967, 214 (5090) :764-&
[5]   EXCEPTIONALLY SMALL SIZE OF SCRAPIE AGENT [J].
ALPER, T ;
HAIG, DA ;
CLARKE, MC .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1966, 22 (03) :278-&
[6]   AMYOTROPHIC-LATERAL-SCLEROSIS ASSOCIATED WITH HOMOZYGOSITY FOR AN ASP90ALA MUTATION IN CUZN-SUPEROXIDE DISMUTASE [J].
ANDERSEN, PM ;
NILSSON, P ;
ALAHURULA, V ;
KERANEN, ML ;
TARVAINEN, I ;
HALTIA, T ;
NILSSON, L ;
BINZER, M ;
FORSGREN, L ;
MARKLUND, SL .
NATURE GENETICS, 1995, 10 (01) :61-66
[7]   SCRAPIE AND CELLULAR PRP ISOFORMS ARE ENCODED BY THE SAME CHROMOSOMAL GENE [J].
BASLER, K ;
OESCH, B ;
SCOTT, M ;
WESTAWAY, D ;
WALCHLI, M ;
GROTH, DF ;
MCKINLEY, MP ;
PRUSINER, SB ;
WEISSMANN, C .
CELL, 1986, 46 (03) :417-428
[8]   DO DEFECTS IN MITOCHONDRIAL ENERGY-METABOLISM UNDERLIE THE PATHOLOGY OF NEURODEGENERATIVE DISEASES [J].
BEAL, MF ;
HYMAN, BT ;
KOROSHETZ, W .
TRENDS IN NEUROSCIENCES, 1993, 16 (04) :125-131
[9]  
BECKMAN JS, 1994, PROG BRAIN RES, V103, P371
[10]   NEARLY UBIQUITOUS TISSUE DISTRIBUTION OF THE SCRAPIE AGENT PRECURSOR PROTEIN [J].
BENDHEIM, PE ;
BROWN, HR ;
RUDELLI, RD ;
SCALA, LJ ;
GOLLER, NL ;
WEN, GY ;
KASCSAK, RJ ;
CASHMAN, NR ;
BOLTON, DC .
NEUROLOGY, 1992, 42 (01) :149-156
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