Blood pressure and body composition in long-term survivors of childhood acute lymphoblastic leukemia

被引:56
作者
Veringa, Susanna J. E. [1 ]
van Dulmen-den Broeder, Eline [1 ]
Kaspers, Gertjan J. L. [1 ]
Veening, Margreet A. [1 ]
机构
[1] Vrije Univ Amsterdam, Med Ctr, Dept Pediat Oncol Hematol, Amsterdam, Netherlands
关键词
ALL; blood pressure; body mass index; late effects; long-term survivors; CARDIOVASCULAR RISK-FACTORS; GROWTH-HORMONE DEFICIENCY; YOUNG-ADULT SURVIVORS; CRANIAL IRRADIATION; METABOLIC SYNDROME; MASS-INDEX; CANCER; CHILDREN; OBESITY; HYPERTENSION;
D O I
10.1002/pbc.23251
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Background Long-term survivors of acute lymphoblastic leukemia (ALL) in childhood are at increased risk of late effects of cancer treatment, among which are cardiovascular sequelae. Purpose of this study was to assess blood pressure and body composition in childhood ALL survivors and compare data to reference values from the general population. compare data to reference values from the general population. Procedure. This single-center retrospective study included 68 survivors of childhood ALL with a median age of 25 years (range 16.4-39.5) and a median follow-up of 16.0 years (range 5.3-30.4). Data on previous treatment, blood pressure and measurements of weight and height at diagnosis and at long-term follow-up (from which body mass index (BMI) was calculated) were obtained from medical records. All data were converted to control-referenced standard deviation scores. Results. Of the ALL survivors 48(1/2)% were prehypertensive and 22.1% were hypertensive. Both the mean systolic (mean SDS 0.736, P < 0.001) and diastolic blood pressure (mean SDS 0.409, P < 0.001) of survivors was significantly higher compared to reference control values. Based on BMI values, 38.2% of the survivors were considered overweight/obese and females, in contrast to males had a significantly higher BMI (mean SDS 1.355, P < 0.001) compared to reference values. In addition, females who had received cranial radiotherapy (mean SDS 2.078) had a significantly higher BMI than females who had not (mean SDS 0.512) (P = 0.009). Conclusions. Both diastolic and systolic blood pressure are significantly increased in survivors of childhood ALL. Female survivors treated with cranial radiation therapy have the highest prevalence and greatest risk of overweight/obesity. Therefore, survivors of childhood ALL are likely to be at an increased risk of cardiovascular disease later in life, which stresses the need for follow-up and adequate medical and/or life style interventions. Pediatr Blood Cancer 2012; 58: 278-282. (C) 2011 Wiley Periodicals, Inc.
引用
收藏
页码:278 / 282
页数:5
相关论文
共 42 条
[1]  
[Anonymous], 2000, WHO TECHN REP SER, V894, pi, DOI DOI 10.1596/0-1952-1129-4
[2]   Association between multiple cardiovascular risk factors and atherosclerosis in children and young adults [J].
Berenson, GS ;
Srinivasan, SR ;
Bao, WH ;
Newman, WP ;
Tracy, RE ;
Wattigney, WA .
NEW ENGLAND JOURNAL OF MEDICINE, 1998, 338 (23) :1650-1656
[3]   INFLUENCE OF AGE, SEX, AND CONCURRENT INTRATHECAL METHOTREXATE THERAPY ON INTELLECTUAL FUNCTION AFTER CRANIAL IRRADIATION DURING CHILDHOOD - A REPORT FROM THE CHILDRENS CANCER STUDY-GROUP [J].
BLEYER, WA ;
FALLAVOLLITA, J ;
ROBISON, L ;
BALSOM, W ;
MEADOWS, A ;
HEYN, R ;
SITARZ, A ;
ORTEGA, J ;
MILLER, D ;
CONSTINE, L ;
NESBIT, M ;
SATHER, H ;
HAMMOND, D .
PEDIATRIC HEMATOLOGY AND ONCOLOGY, 1990, 7 (04) :329-338
[4]  
Blokstra A, 1997, MONITORING RISICOFAC
[5]  
Brennan BMD, 1999, CLIN ENDOCRINOL, V50, P163
[6]   Changes in body composition after childhood cancer treatment: Impact on future health status - A review [J].
Brouwer, C. A. J. ;
Gietema, J. A. ;
Kamps, W. A. ;
de Vries, E. G. E. ;
Postma, A. .
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY, 2007, 63 (01) :32-46
[7]   Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure [J].
Chobanian, AV ;
Bakris, GL ;
Black, HR ;
Cushman, WC ;
Green, LA ;
Izzo, JL ;
Jones, DW ;
Materson, BJ ;
Oparil, S ;
Wright, JT ;
Roccella, EJ .
HYPERTENSION, 2003, 42 (06) :1206-1252
[8]   Obesity and hypertension among children after treatment for acute lymphoblastic leukemia [J].
Chow, Eric J. ;
Pihoker, Catherine ;
Hunt, Kathryn ;
Wilkinson, Karen ;
Friedman, Debra L. .
CANCER, 2007, 110 (10) :2313-2320
[9]   INTELLECTUAL-PERFORMANCE AFTER PRESYMPTOMATIC CRANIAL RADIOTHERAPY FOR LEUKEMIA - EFFECTS OF AGE AND SEX [J].
CHRISTIE, D ;
LEIPER, AD ;
CHESSELLS, JM ;
VARGHAKHADEM, F .
ARCHIVES OF DISEASE IN CHILDHOOD, 1995, 73 (02) :136-140
[10]   Height and weight in children treated for acute lymphoblastic leukemia: Relationship to CNS treatment [J].
Dalton, VK ;
Rue, M ;
Silverman, LB ;
Gelber, RD ;
Asselin, BL ;
Barr, RD ;
Clavell, LA ;
Hurwitz, CA ;
Moghrabi, A ;
Samson, Y ;
Schorin, M ;
Tarbell, NJ ;
Sallan, SE ;
Cohen, LE .
JOURNAL OF CLINICAL ONCOLOGY, 2003, 21 (15) :2953-2960