Aerobic Oxidative Cycloaddition of α-Chlorotosylhydrazones with Arylamines: General Chemoselective Construction of 1,4-Disubstituted and 1,5-Disubstituted 1,2,3-Triazoles under Metal-Free and Azide-Free Conditions

被引：72
作者：
Bai, Hui-Wen
Cai, Zhong-Jian
Wang, Shun-Yi [1 ]
Ji, Shun-Jun
机构：
[1] Soochow Univ, Coll Chem Chem Engn & Mat Sci, Key Lab Organ Synth Jiangsu Prov, Suzhou 215123, Peoples R China
来源：
ORGANIC LETTERS | 2015年 / 17卷 / 12期
基金：
中国国家自然科学基金;
关键词：
RUTHENIUM-CATALYZED CYCLOADDITION; N-TOSYLHYDRAZONES; 1,3-DIPOLAR CYCLOADDITION; REGIOSPECIFIC SYNTHESIS; ALKYNE CYCLOADDITION; TERMINAL ALKYNES; ORGANIC AZIDES; NITROOLEFINS; AZOALKENES; PYRROLES;
D O I：
10.1021/acs.orglett.5b01000
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A novel synthetic approach toward 1,4-disubstituted 1,2,3-triazoles and 1,5-disubstituted 1,2,3-triazoles by aerobic oxidative cycloaddition of alpha-chlorotosylhydrazone with primary aryl amine has been developed. Significantly, the reaction proceeds smoothly to afford 1,4-disubstituted 1,2,3-triazoles and 1,5-disubstituted 1,2,3-triazoles under catalyst-free, metal-free, azide-free, and peroxide-free conditions.
引用
收藏
页码：2898 / 2901
页数：4
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