Aerobic Oxidative Cycloaddition of α-Chlorotosylhydrazones with Arylamines: General Chemoselective Construction of 1,4-Disubstituted and 1,5-Disubstituted 1,2,3-Triazoles under Metal-Free and Azide-Free Conditions

被引：70

作者：

Bai, Hui-Wen

Cai, Zhong-Jian

Wang, Shun-Yi ^{[1
]}

Ji, Shun-Jun

机构：

[1] Soochow Univ, Coll Chem Chem Engn & Mat Sci, Key Lab Organ Synth Jiangsu Prov, Suzhou 215123, Peoples R China

来源：

ORGANIC LETTERS | 2015年 / 17卷 / 12期

基金：

中国国家自然科学基金;

关键词：

RUTHENIUM-CATALYZED CYCLOADDITION; N-TOSYLHYDRAZONES; 1,3-DIPOLAR CYCLOADDITION; REGIOSPECIFIC SYNTHESIS; ALKYNE CYCLOADDITION; TERMINAL ALKYNES; ORGANIC AZIDES; NITROOLEFINS; AZOALKENES; PYRROLES;

D O I：

10.1021/acs.orglett.5b01000

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel synthetic approach toward 1,4-disubstituted 1,2,3-triazoles and 1,5-disubstituted 1,2,3-triazoles by aerobic oxidative cycloaddition of alpha-chlorotosylhydrazone with primary aryl amine has been developed. Significantly, the reaction proceeds smoothly to afford 1,4-disubstituted 1,2,3-triazoles and 1,5-disubstituted 1,2,3-triazoles under catalyst-free, metal-free, azide-free, and peroxide-free conditions.

引用

页码：2898 / 2901

页数：4

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