Parietal Involvement in the Semantic Variant of Primary Progressive Aphasia with Alzheimer's Disease Cerebrospinal Fluid Profile

被引：5

作者：

Bera, Geraldine ^{[1
,2
,3
]}

Migliaccio, Raffaella ^{[2
,3
,4
]}

Michelin, Thibaut ^{[1
]}

Lamari, Foudil ^{[5
]}

Ferrieux, Sophie ^{[4
]}

Nogues, Marie ^{[4
]}

Bertin, Hugo ^{[6
]}

Habert, Marie Odile ^{[1
,6
,7
,8
]}

Dubois, Bruno ^{[2
,3
,4
]}

Teichmann, Marc ^{[2
,3
,4
]}

Kas, Aurelie ^{[1
,6
,7
,8
]}

机构：

[1] Grp Hosp Pitie Salpetriere Charles Foix, AP HP, Serv Med Nucl, Paris 13, France

[2] Sorbonne Univ, CNRS UMR 7225, INSERM U1127, Paris 13, France

[3] Univ Pierre & Marie Curie Paris 6, UMR S 1127, Inst Cerveau & Moelle Epiniere ICM, FrontLab, Paris 13, France

[4] Grp Hosp Pitie Salpetriere Charles Foix, AP HP, Inst Memoire & Malad Alzheimer, Dept Neurol, Paris 13, France

[5] Grp Hosp Pitie Salpetriere Charles Foix, AP HP, Lab Biochim, Paris 13, France

[6] CATI, Http Www Cati Neuroimaging Com, Paris, France

[7] Sorbonne Univ, INSERM U1146, Lab Imagerie Biomed, Paris, France

[8] Univ Pierre & Marie Curie Paris 6, Paris, France

来源：

JOURNAL OF ALZHEIMERS DISEASE | 2018年 / 66卷 / 01期

关键词：

Alzheimer's disease; atypical AD; cerebrospinal fluid examination; parietal lobe; semantic variant of primary progressive aphasia; single photon emission computed tomography; FRONTOTEMPORAL LOBAR DEGENERATION; CSF BIOMARKERS; DEMENTIA; PATHOLOGY; ATROPHY; BRAIN; PRESENTATIONS; VALIDATION; POSITIVITY; CRITERIA;

D O I：

10.3233/JAD-180087

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Semantic variant of primary progressive aphasia (svPPA) is typically associated with non-Alzheimer's disease (AD) pathology. However, some anatomopathological studies have found AD lesions in those patients. We compared brain perfusion SPECT of 18 svPPA patients with cerebrospinal fluid (CSF) biomarkers indicative of non-AD pathology (svPPA-nonAD) and three svPPA patients with CSF biomarkers indicative of underlying AD (svPPA-AD). All svPPA patients had severe left temporopolar hypoperfusion. SvPPA-nonAD had additional anterior cingulate and mediofrontal hypoperfusion, whereas svPPA-AD had greater left parietal and posterior cingulate involvement. Parietal damage in svPPA constitutes a biomarker for underlying Alzheimer pathology thus refining the classification of this PPA variant.

引用

页码：271 / 280

页数：10

共 47 条

[1] Focal cortical presentations of Alzheimer's disease [J].

Alladi, S. ;

Xuereb, J. ;

Bak, T. ;

Nestor, P. ;

Knibb, J. ;

Patterson, K. ;

Hodges, J. R. .

BRAIN, 2007, 130 :2636-2645

[2]

[Anonymous], 2000, BOSTON DIAGNOSTIC AP

[3]

[Anonymous], 1997, Test de denomination orale d'images-DO 80

[4] Amyloid PET Positivity in Different Primary Progressive Aphasia Phenotypes [J].

Beaufils, Emilie ;

Vercouillie, Johnny ;

Vierron, Emilie ;

Cottier, Jean-Philippe ;

Camus, Vincent ;

Mondon, Karl ;

Guilloteau, Denis ;

Hommet, Caroline ;

Ribeiro, Maria Joao .

CLINICAL NUCLEAR MEDICINE, 2018, 43 (04) :E103-E108

[5] CSF biomarkers in frontotemporal lobar degeneration with known pathology [J].

Bian, H. ;

Van Swieten, J. C. ;

Leight, S. ;

Massimo, L. ;

Wood, E. ;

Forman, M. ;

Moore, P. ;

de Koning, I. ;

Clark, C. M. ;

Rosso, S. ;

Trojanowski, J. ;

Lee, V. M. -Y. ;

Grossman, M. .

NEUROLOGY, 2008, 70 (19) :1827-1835

[6] TDP-43 pathology in primary progressive aphasia and frontotemporal dementia with pathologic Alzheimer disease [J].

Bigio, Eileen H. ;

Mishra, Manjari ;

Hatanpaa, Kimmo J. ;

White, Charles L., III ;

Johnson, Nancy ;

Rademaker, Alfred ;

Weitner, Bing Bing ;

Deng, Han-Xiang ;

Dubner, Steven D. ;

Weintraub, Sandra ;

Mesulam, Marsel .

ACTA NEUROPATHOLOGICA, 2010, 120 (01) :43-54

[7] Review and Meta-Analysis of Biomarkers and Diagnostic Imaging in Alzheimer's Disease [J].

Bloudek, Lisa M. ;

Spackman, D. Eldon ;

Blankenburg, Michael ;

Sullivan, Sean D. .

JOURNAL OF ALZHEIMERS DISEASE, 2011, 26 (04) :627-645

[8] Amyloid deposition in semantic dementia: a positron emission tomography study [J].

Brown, Eric E. ;

Graff-Guerrero, Ariel ;

Houle, Sylvain ;

Mizrahi, Romina ;

Wilson, Alan A. ;

Pollock, Bruce G. ;

Mulsant, Benoit H. ;

Felsky, Daniel ;

Voineskos, Aristotle N. ;

Tang-Wai, David F. ;

Verhoeff, Nicolaas P. L. G. ;

Freedman, Morris ;

Ismail, Zahinoor ;

Chow, Tiffany W. .

INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY, 2016, 31 (09) :1064-1074

[9] REGIONAL PATTERN OF DEGENERATION IN ALZHEIMERS-DISEASE - NEURONAL LOSS AND HISTOPATHOLOGICAL GRADING [J].

BRUN, A ;

ENGLUND, E .

HISTOPATHOLOGY, 1981, 5 (05) :549-564

[10] Alzheimer's Disease: The Downside of a Highly Evolved Parietal Lobe? [J].

Bruner, Emiliano ;

Jacobs, Heidi I. L. .

JOURNAL OF ALZHEIMERS DISEASE, 2013, 35 (02) :227-240

← 1 2 3 4 5 →