Mesenchymal Stromal Cell Exosomes in Cardiac Repair

被引:8
作者
Joladarashi, Darukeshwara [1 ]
Kishore, Raj [1 ,2 ]
机构
[1] Temple Univ, Ctr Translat Med, Lewis Katz Sch Med, MERB 953,3500 N Broad St, Philadelphia, PA 19140 USA
[2] Temple Univ, Lewis Katz Sch Med, Dept Cardiovasc Sci, Philadelphia, PA 19140 USA
关键词
Mesenchymal stromal cells; Exosomes; Cardiac fibrosis; Angiogenesis; Inflammation; ACUTE MYOCARDIAL-INFARCTION; INHIBIT CARDIOMYOCYTE APOPTOSIS; STEM-CELLS; HEART-FAILURE; PROTECT; ANGIOGENESIS; THERAPIES; EFFICACY; DISEASES; INJURY;
D O I
10.1007/s11886-022-01660-1
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Purpose of the Review Mesenchymal stromal cells (MSCs) are considered an attractive option for cell-based therapy because of their immune-privileged phenotype and paracrine activity. Substantial preclinical evidence indicates that MSC exosomes recapitulate MSC cellular function in cardiac regeneration and repair. Therefore, in this review, we briefly discuss the latest research progress of MSC exosomes in cardiac repair and regeneration. Recent Findings The recent revolutionary advance in controlling the contents of the exosomes by manipulating parental cells through bioengineering methods to alter specific signaling pathways in ischemic myocardium has proven to be beneficial in the treatment of heart failure. MSC Exosomes appear to be leading candidates to treat myocardial infarction and subsequent heart failure by carrying rich cargo from their parental cells. However, more clinical and pre-clinical studies on MSC exosomes will be required to confirm the beneficial effect to treat cardiovascular diseases
引用
收藏
页码:405 / 417
页数:13
相关论文
共 50 条
[41]   Roles of the Mesenchymal Stromal/Stem Cell Marker Meflin in Cardiac Tissue Repair and the Development of Diastolic Dysfunction [J].
Hara, Akitoshi ;
Kobayashi, Hiroki ;
Asai, Naoya ;
Saito, Shigeyoshi ;
Higuchi, Takahiro ;
Kato, Katsuhiro ;
Okumura, Takahiro ;
Bando, Yasuko K. ;
Takefuji, Mikito ;
Mizutani, Yasuyuki ;
Miyai, Yuki ;
Saito, Shoji ;
Maruyama, Shoichi ;
Maeda, Keiko ;
Ouchi, Noriyuki ;
Nagasaka, Arata ;
Miyata, Takaki ;
Mii, Shinji ;
Kioka, Noriyuki ;
Worthley, Daniel L. ;
Murohara, Toyoaki ;
Takahashi, Masahide ;
Enomoto, Atsushi .
CIRCULATION RESEARCH, 2019, 125 (04) :414-430
[42]   Pretreatment of Cardiac Stem Cells With Exosomes Derived From Mesenchymal Stem Cells Enhances Myocardial Repair [J].
Zhang, Zhiwei ;
Yang, Junjie ;
Yan, Weiya ;
Li, Yangxin ;
Shen, Zhenya ;
Asahara, Takayuki .
JOURNAL OF THE AMERICAN HEART ASSOCIATION, 2016, 5 (01)
[43]   Mesenchymal Stromal Cells and Exosomes: Progress and Challenges [J].
Forsberg, Matthew H. ;
Kink, John A. ;
Hematti, Peiman ;
Capitini, Christian M. .
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2020, 8
[44]   Progress of Mesenchymal Stem Cell-Derived Exosomes in Tissue Repair [J].
Zhao, Guifang ;
Ge, Yiwen ;
Zhang, Chenyingnan ;
Zhang, Leyi ;
Xu, Junjie ;
Qi, Ling ;
Li, Wenliang .
CURRENT PHARMACEUTICAL DESIGN, 2020, 26 (17) :2022-2037
[45]   Tumour cell-derived exosomes endow mesenchymal stromal cells with tumour-promotion capabilities [J].
Lin, L. Y. ;
Du, L. M. ;
Cao, K. ;
Huang, Y. ;
Yu, P. F. ;
Zhang, L. Y. ;
Li, F. Y. ;
Wang, Y. ;
Shi, Y. F. .
ONCOGENE, 2016, 35 (46) :6038-6042
[46]   Mesenchymal Stem Cell Derived Exosomes Therapy in Diabetic Wound Repair [J].
Jing, Shengyu ;
Li, Hongjie ;
Xu, Hongbo .
INTERNATIONAL JOURNAL OF NANOMEDICINE, 2023, 18 :2707-2720
[47]   Effect of Human Corneal Mesenchymal Stromal Cell-derived Exosomes on Corneal Epithelial Wound Healing [J].
Samaeekia, Ravand ;
Rabiee, Behnam ;
Putra, Ilham ;
Shen, Xiang ;
Park, Young Jae ;
Hematti, Peiman ;
Eslani, Medi ;
Djalilian, Ali R. .
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2018, 59 (12) :5194-5200
[48]   Mesenchymal Stromal Cell-Derived Extracellular Vesicles Protect the Fetal Brain After Hypoxia-Ischemia [J].
Ophelders, Daan R. M. G. ;
Wolfs, Tim G. A. M. ;
Jellema, Reint K. ;
Zwanenburg, Alex ;
Andriessen, Peter ;
Delhaas, Tammo ;
Ludwig, Anna-Kristin ;
Radtke, Stefan ;
Peters, Vera ;
Janssen, Leon ;
Giebel, Bernd ;
Kramer, Boris W. .
STEM CELLS TRANSLATIONAL MEDICINE, 2016, 5 (06) :754-763
[49]   Umbilical Cord Mesenchymal Stromal Cell-Derived Exosomes Rescue the Loss of Outer Hair Cells and Repair Cochlear Damage in Cisplatin-Injected Mice [J].
Tsai, Stella Chin-Shaw ;
Yang, Kuender D. ;
Chang, Kuang-Hsi ;
Lin, Frank Cheau-Feng ;
Chou, Ruey-Hwang ;
Li, Min-Chih ;
Cheng, Ching-Chang ;
Kao, Chien-Yu ;
Chen, Chie-Pein ;
Lin, Hung-Ching ;
Hsu, Yi-Chao .
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021, 22 (13)
[50]   MESENCHYMAL STROMAL CELL THERAPY FOR CARTILAGE REPAIR [J].
Gerth, A. ;
Opitz, C. H. ;
Oldak, T. .
CYTOTHERAPY, 2021, 23 (05) :S67-S68