Prospects of stem cell therapy in osteoarthritis

被引：1

作者：

Roberts, Sally ^{[1
]}

Genever, Paul ^{[1
,2
]}

McCaskie, Andrew ^{[1
,3
,4
]}

De Bari, Cosimo ^{[1
,5
]}

机构：

[1] Arthritis Res UK Tissue Engn Ctr, Kobe, Hyogo, Japan

[2] Univ York, Dept Biol, York YO10 5DD, N Yorkshire, England

[3] Newcastle Univ, Musculoskeletal Res Grp, Inst Cellular Med, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England

[4] Newcastle Upon Tyne Hosp NHS Fdn Trust, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England

[5] Univ Aberdeen, Musculoskeletal Programme, Sch Med & Dent, Inst Med Sci, Aberdeen AB25 2ZD, Scotland

来源：

REGENERATIVE MEDICINE | 2011年 / 6卷 / 03期

基金：

英国医学研究理事会;

关键词：

articular cartilage; bone; immunomodulatory; mesenchymal stem cell; stem cell niches; HUMAN BONE-MARROW; SPONTANEOUS MALIGNANT-TRANSFORMATION; CHONDROGENIC PROGENITOR CELLS; SYMPTOMATIC CARTILAGE DEFECTS; MESENCHYMAL STROMAL CELLS; IN-VITRO; IMMUNOMODULATORY PROPERTIES; INTERNATIONAL-SOCIETY; CROSS-CONTAMINATION; TELOMERASE ACTIVITY;

D O I：

10.2217/RME.11.21

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Osteoarthritis is a common disorder in which there is not only extensive degeneration but also an aberrant attempt at repair in joints. Stem cell therapy could provide a permanent, biological solution, with all sources of stem cells (embryonic, fetal and adult) showing some degree of potential. Mesenchymal stromal/stem cells, however, appear to be the leading candidates because of their ability to be sourced from many or all joint tissues. They may also modulate the immune response of individuals, in a manner influenced by local factors. This biological behavior of stem cells renders the application of regulatory standardizations challenging in comparison to pharmaceutical therapies. However, this would not be an issue if endogenous stem cells were activated to effect repair of an arthritic joint.

引用

页码：351 / 366

页数：16

共 152 条

[1] Human mesenchymal stem cells modulate allogeneic immune cell responses [J].

Aggarwal, S ;

Pittenger, MF .

BLOOD, 2005, 105 (04) :1815-1822

[2]

[Anonymous], 2006, J CELL SCI

[3]

*ARTHR CAR, OA NAT MOST COMPR UK

[4] Successful treatment of refractory tibial nonunion using calcium sulphate and bone marrow stromal cell implantation [J].

Bajada, S. ;

Harrison, P. E. ;

Ashton, B. A. ;

Cassar-Pullicino, V. N. ;

Ashammakhi, N. ;

Richardson, J. B. .

JOURNAL OF BONE AND JOINT SURGERY-BRITISH VOLUME, 2007, 89B (10) :1382-1386

[5] Decreased osteogenesis, increased cell senescence and elevated Dickkopf-1 secretion in human fracture non union stromal cells [J].

Bajada, Stefan ;

Marshall, Michael J. ;

Wright, Karina T. ;

Richardson, James B. ;

Johnson, William E. B. .

BONE, 2009, 45 (04) :726-735

[6]

BARKER M, 2009, NATURE, V458, P962

[7]

BARKER M, 2010, NATURE, V463, P719

[8] Mesenchymal stem cells suppress lymphocyte proliferation in vitro and prolong skin graft survival in vivo [J].

Bartholomew, A ;

Sturgeon, C ;

Siatskas, M ;

Ferrer, K ;

McIntosh, K ;

Patil, S ;

Hardy, W ;

Devine, S ;

Ucker, D ;

Deans, R ;

Moseley, A ;

Hoffman, R .

EXPERIMENTAL HEMATOLOGY, 2002, 30 (01) :42-48

[9] Introducing Transcription Factors to Multipotent Mesenchymal Stem Cells: Making Transdifferentiation Possible [J].

Barzilay, Ran ;

Melamed, Eldad ;

Offen, Daniel .

STEM CELLS, 2009, 27 (10) :2509-2515

[10]

BHOSALE A, 2009, AM J SPORTS MED, V20, P1

← 1 2 3 4 5 6 7 8 9 10 →