Benefits and adverse events of melatonin use in the elderly (Review)

被引：42

作者：

Anghel, Lucretia ^{[1
]}

Baroiu, Liliana ^{[1
]}

Popazu, Corina Risca ^{[1
]}

Patras, Diana ^{[2
]}

Fotea, Silvia ^{[1
]}

Nechifor, Alexandru ^{[1
,3
]}

Ciubara, Anamaria ^{[1
]}

Nechita, Luiza ^{[1
]}

Musat, Carmina Liana ^{[4
]}

Stefanopol, Ioana Anca ^{[4
]}

Tatu, Alin Laurentiu ^{[1
,3
,5
]}

Ciubara, Alexandru Bogdan ^{[4
]}

机构：

[1] Univ Galatzi, Fac Med & Pharm, Clin Med Dept, 35 AI Cuza St, Galati 800008, Romania

[2] St Andrew Apostle Clin Emergency Cty Hosp, Internal Med Dept, Galati 800578, Romania

[3] Univ Galatzi, Multidisciplinary Integrated Ctr Dermatol Interfa, Galati 800008, Romania

[4] Univ Galatzi, Dept Morphol & Funct Sci, Fac Med & Pharm, Galati 800008, Romania

[5] Univ Galatzi, Res Ctr Field Med & Pharmaceut Sci, Galati 800008, Romania

来源：

EXPERIMENTAL AND THERAPEUTIC MEDICINE | 2022年 / 23卷 / 03期

关键词：

melatonin; elderly; benefits; safety; long-term use; UV-INDUCED ERYTHEMA; BLOOD-PRESSURE; BETA-BLOCKERS; MAGNESIUM SUPPLEMENTATION; IN-VITRO; SKIN; METABOLISM; DAMAGE; SLEEP; ANTIOXIDANT;

D O I：

10.3892/etm.2022.11142

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Melatonin is a hormone secreted by the pineal gland in accordance with the circadian rhythm when the light level decreases. Reduction of melatonin secretion with age may be associated with physiological aging in neurodegenerative diseases by affecting the suprachiasmatic nucleus or of the neuronal pathways of transmission to the pineal gland. A significant decrease in melatonin synthesis has been reported in various disorders and diseases, including cardiovascular diseases, metabolic disorders (particularly diabetes type 2), cancer and endocrine diseases. In addition to the fact, that melatonin is a sleep inducer, it also exerts cytoprotective properties as an antioxidant and free radical scavenger. The therapeutic role of melatonin has been demonstrated in sleep disorders, eye damage and cardiovascular disease. The association between melatonin and beta-blockers has had a positive impact on sleep disorders in clinical trials. Previous studies have reported the anti-inflammatory effect of melatonin by adjusting levels of pro-inflammatory cytokines, including interleukin (IL)-6, IL-1 beta and tumor necrosis factor-alpha. Melatonin treatment has been demonstrated to decrease IL-6 and IL-10 expression levels and efficiently attenuate T-cell proliferation. Currently, there is an inconsistency of scientific data regarding the lowest optimal dose and safety of melatonin for long-term use. The aim of the present review was to summarize the evidence on the role of melatonin in various clinical conditions and highlight the future research in this area.

引用

页数：8

共 118 条

[1]

Abbasi B, 2012, J RES MED SCI, V17, P1161

[2] Extrapineal melatonin: sources, regulation, and potential functions [J].

Acuna-Castroviejo, Dario ;

Escames, Germaine ;

Venegas, Carmen ;

Diaz-Casado, Maria E. ;

Lima-Cabello, Elena ;

Lopez, Luis C. ;

Rosales-Corral, Sergio ;

Tan, Dun-Xian ;

Reiter, Russel J. .

CELLULAR AND MOLECULAR LIFE SCIENCES, 2014, 71 (16) :2997-3025

[3] Scientific Opinion on the substantiation of a health claim related to melatonin and reduction of sleep onset latency (ID 1698, 1780, 4080) pursuant to Article 13(1) of Regulation (EC) No 1924/2006 [J].

Agostoni, Carlo ;

Bresson, Jean-Louis ;

Fairweather-Tait, Susan ;

Flynn, Albert ;

Golly, Ines ;

Korhonen, Hannu ;

Lagiou, Pagona ;

Lovik, Martinus ;

Marchetti, Rosangela ;

Martin, Ambroise ;

Moseley, Bevan ;

Neuhauser-Berthold, Monika ;

Przyrembel, Hildegard ;

Salminen, Seppo ;

Sanz, Yolanda ;

Strain, Sean ;

Strobel, Stephan ;

Tetens, Inge ;

Tome, Daniel ;

van Loveren, Hendrik ;

Verhagen, Hans .

EFSA JOURNAL, 2011, 9 (06)

[4] Direct monitoring of UV-induced free radical generation in HaCaT keratinocytes [J].

Aitken, G. R. ;

Henderson, J. R. ;

Chang, S.-C. ;

McNeil, C. J. ;

Birch-Machin, M. A. .

CLINICAL AND EXPERIMENTAL DERMATOLOGY, 2007, 32 (06) :722-727

[5]

Akindele O O, 2014, Afr J Med Med Sci, V43, P295

[6] PLASMA-CONCENTRATIONS OF MELATONIN IN MAN FOLLOWING ORAL ABSORPTION OF DIFFERENT PREPARATIONS [J].

ALDHOUS, M ;

FRANEY, C ;

WRIGHT, J ;

ARENDT, J .

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 1985, 19 (04) :517-521

[7] Melatonin: therapeutic and clinical utilization [J].

Altun, A. ;

Ugur-Altun, B. .

INTERNATIONAL JOURNAL OF CLINICAL PRACTICE, 2007, 61 (05) :835-845

[8] A systematic review of peri-operative melatonin [J].

Andersen, L. P. H. ;

Werner, M. U. ;

Rosenberg, J. ;

Goegenur, I. .

ANAESTHESIA, 2014, 69 (10) :1163-1171

[9]

Bangha E, 1996, ARCH DERMATOL RES, V288, P522, DOI 10.1007/BF02505248

[10] Assessment of Depression in Patients with COVID-19 [J].

Baroiu, Liliana ;

Dumea, Elena ;

Nastase, Florentina ;

Niculet, Elena ;

Fotea, Silvia ;

Ciubara, Alexandru Bogdan ;

Stefanopol, Ioana Anca ;

Nechita, Aurel ;

Anghel, Lucretia ;

Ciubara, Anamaria .

BRAIN-BROAD RESEARCH IN ARTIFICIAL INTELLIGENCE AND NEUROSCIENCE, 2021, 12 (02) :254-264

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