Synthetic studies toward potent cytotoxic agents amphidinolides:: Synthesis of the C1-C18 moiety of amphidinolides G, H and L

被引：24

作者：

Chakraborty, TK ^{[1
]}

Suresh, VR ^{[1
]}

机构：

[1] Indian Inst Chem Technol, Hyderabad 500007, Andhra Pradesh, India

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 49期

关键词：

amphidinolides; antitumor compounds; macrolides; asymmetric alkylation;

D O I：

10.1016/S0040-4039(98)02009-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Stereoselective synthesis of the (8S, 9S, 11R, 16S)-C-1-C-18 Segment 1 of amphidinolides G, H and L, bearing the unique trisubstituted "s-cis-1,3-diene" moiety (C-28(29)=C-13-C-14=C-15), has been achieved for the first time following a highly efficient convergent strategy. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：9109 / 9112

页数：4

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