Monoclonal antibodies in the treatment of advanced colorectal cancer

被引：13

作者：

Capdevila, J. ^{[1
]}

Saura, C. ^{[1
]}

Macarulla, T. ^{[1
]}

Casado, E. ^{[1
]}

Ramos, F. J. ^{[1
]}

Tabernero, J. ^{[1
]}

机构：

[1] Vall Hebron Univ Hosp, Dept Med Oncol, Barcelona, Spain

来源：

EJSO | 2007年 / 33卷

关键词：

colorectal cancer; monoclonal antibodies; targeted therapy; cetuximab; bevacizumab; panitumumab;

D O I：

10.1016/j.ejso.2007.09.025

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Despite the advances obtained in recent years in the treatment of metastatic colorectal cancer, the prognosis remains poor. An emerging understanding of the molecular pathways has provided novel targets in cancer therapy to improve these results. Emerging data from the clinical development of new drugs against these targets is providing novel opportunities in the treatment of patients with colorectal cancer. There is a need to optimize and define the best use of these new approaches. In this review, the authors examine the current development status of monoclonal antibodies in the treatment of advanced colorectal cancer. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：S24 / S34

页数：11

共 64 条

[1] The ErbB signaling network in embryogenesis and oncogenesis: Signal diversification through combinatorial ligand-receptor interactions [J].

Alroy, I ;

Yarden, Y .

FEBS LETTERS, 1997, 410 (01) :83-86

[2]

[Anonymous], P AM SOC CLIN ONCOL

[3]

ASLTZ LB, 2007, ASCO GASTR CANC S

[4] Phase I safety, pharmacokinetic, and pharmacodynamic trial of ZD1839, a selective oral epidermal growth factor receptor tyrosine kinase inhibitor, in patients with five selected solid tumor types [J].

Baselga, J ;

Rischin, D ;

Ranson, M ;

Calvert, H ;

Raymond, E ;

Kieback, DG ;

Kaye, SB ;

Gianni, L ;

Harris, A ;

Bjork, T ;

Averbuch, SD ;

Feyereislova, A ;

Swaisland, H ;

Rojo, F ;

Albanell, J .

JOURNAL OF CLINICAL ONCOLOGY, 2002, 20 (21) :4292-4302

[5]

BASELGA J, 2006, P AM SOC CLIN ONOCL, V24, pS18

[6]

BASELGA J, 2000, SIGNAL, V1, P12

[7]

BENDELL JC, 2006, P AN M AM SOC CLIN, V24, pS18

[8]

BERRY SR, 2006, P AN M AM SOC CLIN, V24, pS18

[9]

BORNER M, 2006, P AN M AM SOC CLIN, V24, pS18

[10]

Brabender J, 2001, CLIN CANCER RES, V7, P1850

← 1 2 3 4 5 6 7 →