A new lignan glycoside from the fruits of Cornus kousa Burg.

被引：14

作者：

Lee, Dae-Young ^{[1
,2
]}

Yoo, Ki-Hyun ^{[1
,2
]}

Chung, In-Sik ^{[1
,2
]}

Kim, Ji-Young ^{[1
,2
]}

Chung, Dae-Kyun ^{[1
,2
]}

Kim, Dae-Keun ^{[3
]}

Kim, Sung-Hoon ^{[4
]}

Baek, Nam-In ^{[1
,2
]}

机构：

[1] Kyung Hee Univ, Grad Sch Biotechnol, Yongin 446701, South Korea

[2] Kyung Hee Univ, Plant Metab Res Ctr, Yongin 446701, South Korea

[3] Woosuk Univ, Dept Pharm, Jeonju 565701, South Korea

[4] Kyung Hee Univ, Grad Sch Oriental Med, Seoul 130701, South Korea

来源：

ARCHIVES OF PHARMACAL RESEARCH | 2008年 / 31卷 / 07期

关键词：

Cornus kousa; lignan glycoside; cornuskoside A; (-)-balanophonin; (7; S; 8 ' R)-dihydrodehydrodiconiferyl alcohol; cytotoxicity;

D O I：

10.1007/s12272-001-1233-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new lignan glycoside, (7'S, 8'R)-dihydrodehydrodiconiferyl alcohol-4'-O-beta-D-xylopyranoside (1), named cornuskoside A, was isolated from the fruits of Cornus kousa. The structure of the compound was determined by spectroscopy, including FABMS, UV, IR, (1)H- and (13)C-NMR, DEPT and 2D-NMR (COSY, HSQC, and HMBC). This new lignan glycoside, along with its aglycone, (7'S, 8'R)-dihydrodehydrodiconiferyl alcohol (3), and another lignan with a similar skeleton, (-)-balanophonin (2), which have been previously isolated from this plant, were evaluated for cytotoxicity in human cancer cell lines such as HeLa, MCF-7, SK-MEL-5, and SK-OV-3. Compounds 2 and 3 showed cytotoxicity against HeLa [IC(50) = 29.1 mu M (2), 45.5 mu M (3)], MCF-7 [IC(50) = 29.2 mu M (2), 28.2 mu M (3)], SK-MEL-5 [IC(50) = 31.3 mu M (2), 32.3 mu M (3)], and SK-OV-3 [IC(50) = 33.4 mu M (2), 43.4 mu M (3)] cell lines.

引用

页码：830 / 833

页数：4

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