Physicochemical and thermodynamic characterization of hydroxy pentacyclic triterpenoic acid/γ-cyclodextrin inclusion complexes

被引：15

作者：

Fontanay, Stephane ^{[1
]}

Kedzierewicz, Francine ^{[1
]}

Duval, Raphael Emmanuel ^{[1
]}

Clarot, Igor ^{[1
]}

机构：

[1] Nancy Univ, CNRS, SRSMC, Fac Pharm, F-54001 Nancy, France

来源：

JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY | 2012年 / 73卷 / 1-4期

关键词：

HPTA; gamma-Cyclodextrin; HPLC; NMR; DSC; OLEANOLIC ACID; URSOLIC ACID; IN-VITRO; SYSTEMS;

D O I：

10.1007/s10847-011-0063-y

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Hydroxy pentacyclic triterpenoic acids (HPTAs) have been described to exhibit numerous pharmacological properties. They also exhibit poor hydrosolubility, thus affecting their potential clinical interest. The association of these active substances with cyclodextrins could be employed to improve some properties such as bioavailability and activity. 1:1 Inclusion complexes of ursolic, oleanolic and betulinic acids with gamma-cyclodextrin were evaluated by DSC and H-1 NMR spectroscopy. The apparent formation constants (K-f) of the formed complexes were determined using RP-HPLC. Thermodynamic parameters Delta GA(0), Delta HA(0) and Delta SA(0) were calculated with temperatures ranging from 25 to 45 A degrees C to evaluate the complexation process. Finally the influence of gamma-CD on the HPTA water solubility was investigated by phase-solubility studies.

引用

页码：341 / 347

页数：7

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