Proteasome activation: An innovative promising approach for delaying aging and retarding age-related diseases

被引：81

作者：

Chondrogianni, Niki ^{[1
]}

Voutetakis, Konstantinos ^{[1
]}

Kapetanou, Marianna ^{[1
]}

Delitsikou, Vasiliki ^{[1
]}

Papaevgeniou, Nikoletta ^{[1
]}

Sakellari, Marianthi ^{[1
,2
]}

Lefaki, Maria ^{[1
]}

Filippopoulou, Konstantina ^{[1
]}

Gonos, Efstathios S. ^{[1
,2
]}

机构：

[1] Natl Hellen Res Fnd, Inst Biol Med Chem & Biotechnol, Athens 11635, Greece

[2] Univ Orebro, Sch Med, SE-70182 Orebro, Sweden

来源：

AGEING RESEARCH REVIEWS | 2015年 / 23卷

关键词：

Ubiquitin-proteasome system; Proteasome activation; Aging; Senescence; Longevity; Age-related diseases; AMYOTROPHIC-LATERAL-SCLEROSIS; HUTCHINSON-GILFORD PROGERIA; ELEGANS LIFE-SPAN; ENDOPLASMIC-RETICULUM STRESS; ALPHA-SYNUCLEIN AGGREGATION; OXIDIZED PROTEIN REMOVAL; WERNER-SYNDROME PROTEIN; EMBRYONIC STEM-CELLS; DOUBLE-STRAND BREAKS; DNA-DAMAGE RESPONSE;

D O I：

10.1016/j.arr.2014.12.003

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Aging is a natural process accompanied by a progressive accumulation of damage in all constituent macromolecules (nucleic acids, lipids and proteins). Accumulation of damage in proteins leads to failure of proteostasis (or vice versa) due to increased levels of unfolded, misfolded or aggregated proteins and, in turn, to aging and/or age-related diseases. The major cellular proteolytic machineries, namely the proteasome and the lysosome, have been shown to dysfunction during aging and age-related diseases. Regarding the proteasome, it is well established that it can be activated either through genetic manipulation or through treatment with natural or chemical compounds that eventually result to extension of lifespan or deceleration of the progression of age-related diseases. This review article focuses on proteasome activation studies in several species and cellular models and their effects on aging and longevity. Moreover, it summarizes findings regarding proteasome activation in the major age-related diseases as well as in progeroid syndromes. (C) 2014 Elsevier B.V. All rights reserved.

引用

页码：37 / 55

页数：19

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