Spithioneines A and B, Two New Bohemamine Derivatives Possessing Ergothioneine Moiety from a Marine-Derived Streptomyces spinoverrucosus

被引：41

作者：

Fu, Peng ^{[1
]}

MacMillan, John B. ^{[1
]}

机构：

[1] Univ Texas SW Med Ctr Dallas, Dept Biochem, Dallas, TX 75390 USA

来源：

ORGANIC LETTERS | 2015年 / 17卷 / 12期

关键词：

S BOND FORMATION; NATURAL-PRODUCTS; A-C; ANTITUMOR-ANTIBIOTICS; BACILLUS-HUNANENSIS; METABOLITES; INHIBITORS; DISCOVERY; ACTINOBACTERIA; BIOSYNTHESIS;

D O I：

10.1021/acs.orglett.5b01328

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Spithioneines A and B (1 and 2), two new bohemamine-type pyrrolizidine alkaloids possessing an unusual ergothioneine moiety, were isolated from a marine-derived Streptomyces spinoverrucosus. Their structures were elucidated by spectroscopic analysis, CD spectra, and chemical degradation and synthesis. Compounds 1 and 2 are rare natural products that incorporate the amino acid ergothioneine.

引用

页码：3046 / 3049

页数：4