Antioxidant strategies in the treatment of stroke

被引：376
作者：
Margaill, I [1 ]
Plotkine, M [1 ]
Lerouet, D [1 ]
机构：
[1] Univ Paris 05, Pharmacol Lab, UPRES EA 2510, Paris, France
来源：
FREE RADICAL BIOLOGY AND MEDICINE | 2005年 / 39卷 / 04期
关键词：
focal cerebral ischemia; free radicals; oxidative stress;
D O I：
10.1016/j.freeradbiomed.2005.05.003
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Excessive production of free radicals is known to lead to cell injury in a variety of diseases, such as cerebral ischemia. In this review, we describe some of the numerous studies that have examined this oxidative stress and the efficiency of antioxidant strategies in focal cerebral ischemia. Besides using genetically modified mice, these strategies can be divided into three groups: (1) inhibition of free radical production, (2) scavenging of free radicals, and (3) increase of free radical degradation by using agents mimicking the enzymatic activity of endogenous antioxidants. Finally, the clinical trials that have tested or are currently testing the efficiency of antioxidants in patients suffering from stroke are reviewed. The results presented here lead us to consider that antioxidants are very promising drugs for the treatment of ischemic stroke. (c) 2005 Elsevier Inc. All rights reserved.
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收藏
页码：429 / 443
页数：15
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