Acarbose attenuates experimental non-alcoholic steatohepatitis

被引：41

作者：

Lieber, CS ^{[1
]}

Leo, MA ^{[1
]}

Mak, KM ^{[1
]}

Xu, YQ ^{[1
]}

Cao, Q ^{[1
]}

Ren, CL ^{[1
]}

Ponomarenko, A ^{[1
]}

DeCarli, LM ^{[1
]}

机构：

[1] Mt Sinai Sch Med, Vet Affairs Med Ctr, Sect Liver Dis & Nutr, Alcohol Res & Treatment Ctr, Bronx, NY USA

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2004年 / 315卷 / 03期

关键词：

alpha-glucosidase inhibitor; acarbose; diabetes; inflammation; TNF-alpha; CYP2E1; collagen;

D O I：

10.1016/j.bbrc.2004.01.116

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The alpha-glucosidase inhibitor acarbose is beneficial in the prevention of type 2 diabetes. To determine whether it attenuates the commonly associated non-alcoholic steatohepatitis (NASH), we used an experimental NASH model. Rats were fed ad libitum a nutritionally adequate high fat diet (71% of calories as fat) with or without acarbose (200 mg/1000 calories) for 3 weeks. All rats given the high fat diet only developed typical NASH whereas acarbose attenuated several of the characteristic hepatic alterations of NASH: there was less steatosis and inflammation, with a significant reduction in the mRNA of the hepatic inflammatory cytokine TNF-alpha and of its protein. There was also a decrease in the CYP2E1 mRNA and in collagen, with similar trends for CYP2E1 protein and procollagen mRNA. Because acarbose attenuates many of the hepatic alterations associated with experimental NASH, it is now indicated to determine whether it exerts similar beneficial effects in patients afflicted by this disease. (C) 2004 Elsevier Inc. All rights reserved.

引用

页码：699 / 703

页数：5

共 25 条

[1] Hepatic cytochrome p450 2E1 activity in nondiabetic patients with nonalcoholic steatohepatitis [J].