One-Pot Reductive Amination and Suzuki-Miyaura Cross-Coupling of Formyl Aryl and Heteroaryl MIDA Boronates in Array Format

被引：31

作者：

Grob, Jonathan E. ^{[1
]}

Nunez, Jill ^{[1
]}

Dechantsreiter, Michael A. ^{[1
]}

Hamann, Lawrence G. ^{[1
]}

机构：

[1] Novartis Inst BioMed Res Inc, Cambridge, MA 02139 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2011年 / 76卷 / 12期

关键词：

BORONIC ACIDS; BIOLOGICAL EVALUATION; EFFICIENT; COMPLEXES; RECEPTOR;

D O I：

10.1021/jo2005928

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Formyl-substituted aryl and heteroaryl MIDA boronates were prepared by a DMSO-free method and used in the first reported one-pot reductive amination-Suzuki-Miyaura cross-coupling sequence. This sequence was then carried out in parallel array format, using microwave-assisted in situ release cross-coupling of MLDA boronates to generate a library with diversity along two axes, affording rapid and convenient access to an array of druglike molecules.

引用

页码：4930 / 4940

页数：11

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