IL-33 is associated with unfavorable postoperative survival of patients with clear-cell renal cell carcinoma

被引：12
作者：
Wang, Zewei [1 ]
Xu, Le [2 ]
Chang, Yuan [3 ]
Zhou, Lin [3 ]
Fu, Hangcheng [1 ]
Zhang, Weijuan [4 ]
Yang, Yuanfeng [3 ]
Xu, Jiejie [1 ]
机构：
[1] Fudan Univ, Sch Basic Med Sci, Dept Biochem & Mol Biol, Shanghai 200032, Peoples R China
[2] Shanghai Jiao Tong Univ, Sch Med, Ruijin Hosp, Dept Urol, Shanghai, Peoples R China
[3] Fudan Univ, Zhongshan Hosp, Dept Urol, Shanghai 200032, Peoples R China
[4] Fudan Univ, Sch Basic Med Sci, Dept Immunol, Shanghai, Peoples R China
来源：
TUMOR BIOLOGY | 2016年 / 37卷 / 08期
基金：
中国国家自然科学基金;
关键词：
Clear-cell renal cell carcinoma; Interleukin-33; Prognostic biomarker; Overall survival; ACQUIRED-IMMUNITY; CANCER; EXPRESSION; INNATE; ST2; INTERLEUKIN-33; CONTRIBUTES; MACROPHAGES; CYTOKINE; PATHWAY;
D O I：
10.1007/s13277-016-4879-3
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The aim of this study was to evaluate the potential prognostic significance of interleukin-33 (IL-33) in patients with clear-cell renal cell carcinoma (ccRCC) after surgical resection. In this retrospective research, we enrolled 203 patients with ccRCC undergoing nephrectomy between 2003 and 2004 in a single institution. We recorded clinicopathologic features, overall survival (OS), and recurrence-free survival (RFS) and assessed IL-33 expression by immunohistochemical staining. On such bases, the correlations between IL-33 expression and clinicopathologic features and prognosis were evaluated. A high expression of IL-33 was significantly associated with advanced TNM stage and Fuhrman grade (p = 0.017 and p < 0.001, respectively) in patients with ccRCC. Moreover, multivariate analysis identified IL-33 as an independent prognostic factor of OS for patients with ccRCC after surgery (hazard ratio = 2.050; 95 % CI 1.223-3.447; p = 0.006). The incorporation of IL-33 into the TNM stage and Fuhrman grade might help to refine individual risk stratification. The IL-33 expression may serve as an independent negative predictor of survival for patients with ccRCC after surgery.
引用
收藏
页码：11127 / 11134
页数：8
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