Synergistic Anti-tumor Effect of Dichloroacetate and Ivermectin

被引：5

作者：

Ishiguro, Tatsuaki ^{[1
]}

Ishiguro, Ryumei H. ^{[1
]}

Ishiguro, Miyu ^{[1
]}

Toki, Atsushi ^{[2
]}

Terunuma, Hiroshi ^{[3
]}

机构：

[1] Kamui Med Co Ltd, Tumor Biol, Tokyo, Japan

[2] Tama Nanbu Child Hosp, Internal Med, Tokyo, Japan

[3] N2 Clin Yotsuya, Internal Med, Tokyo, Japan

来源：

CUREUS JOURNAL OF MEDICAL SCIENCE | 2022年 / 14卷 / 02期

关键词：

sarcoma; cancer; tamoxifen; omeprazole; ivermectin; dichloroacetate; CANCER; APOPTOSIS; THERAPY; TUMORS;

D O I：

10.7759/cureus.21884

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We formerly reported that the combination of dichloroacetate, omeprazole, and tamoxifen blocked cancer progression by reducing lactic acid production and inducing superoxide production. Recently, ivermectin, a well-known anti-parasite drug, was reported to share the same mechanisms with them and have anti-tumor activity. Here, we present three patients in whom the combination of dichloroacetate, omeprazole (plus tamoxifen), and ivermectin dramatically relieved the symptoms accompanying cancer and sarcoma progression.

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页数：6

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