Three US Food and Drug Administration-approved therapies for chronic GVHD

被引：46

作者：

Zeiser, Robert ^{[1
]}

Lee, Stephanie J. ^{[2
,3
]}

机构：

[1] Univ Freiburg, Dept Med 1, Med Ctr, Fac Med, Freiburg, Germany

[2] Univ Washington, Fred Hutchinson Canc Res Ctr, Clin Res Div, Seattle, WA USA

[3] Univ Washington, Dept Med, Seattle, WA USA

来源：

BLOOD | 2022年 / 139卷 / 11期

基金：

美国国家卫生研究院;

关键词：

VERSUS-HOST-DISEASE; CONSENSUS DEVELOPMENT PROJECT; CLINICAL-TRIALS; CRITERIA; IBRUTINIB; RUXOLITINIB; PREVENTION; DIAGNOSIS; MURINE; IV;

D O I：

10.1182/blood.2021014448

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Chronic graft-versus-host disease ( cGVHD) is a major immunologic complication of allogeneic hematopoietic cell transplantation. cGVHD involves multiple organs, reduces quality of life, and often requires prolonged therapy with glucocorticoids, causing severe side effects. After 4 decades of testing multiple therapeutic approaches, ibrutinib, belumosudil, and ruxolitinib were US Food and Drug Administration approved for cGVHD in the last 4 years. Here we put a spotlight on their mechanisms of action, studies that led to approval, and their future role in cGVHD.

引用

页码：1642 / 1645

页数：4

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