Proliferation, cell cycle and apoptosis in cancer

被引：2853

作者：

Evan, GI

Vousden, KH

机构：

[1] Univ Calif San Francisco, Ctr Canc, San Francisco, CA 94143 USA

[2] NCI, Frederick, MD 20842 USA

来源：

NATURE | 2001年 / 411卷 / 6835期

关键词：

D O I：

10.1038/35077213

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Beneath the complexity and idiopathy of every cancer lies a limited number of 'mission critical' events that have propelled the tumour cell and its progeny into uncontrolled expansion and invasion. One of these is deregulated cell proliferation, which, together with the obligate compensatory suppression of apoptosis needed to support it, provides a minimal 'platform' necessary to support further neoplastic progression. Adroit targeting of these critical events should have potent and specific therapeutic consequences.

引用

页码：342 / 348

页数：7

共 92 条

[1] DEFICIENCY OF RETINOBLASTOMA PROTEIN LEADS TO INAPPROPRIATE S-PHASE ENTRY, ACTIVATION OF E2F-RESPONSIVE GENES, AND APOPTOSIS [J].