Synthesis of γ-lactams via trifluoromethylative aminocarbonylation of unactivated olefins

被引：2
作者：
Liu, Jige [1 ]
Chen, Dong [1 ,2 ]
Ji, Meishan [1 ]
Wu, Xinxin [1 ]
Zhu, Chen [1 ]
机构：
[1] Soochow Univ, Coll Chem Chem Engn & Mat Sci, Key Lab Organ Synth Jiangsu Prov, 199 Ren Ai Rd, Suzhou 215123, Jiangsu, Peoples R China
[2] Henan Univ Engn, Sch Mat & Chem Engn, Zhengzhou 451191, Henan, Peoples R China
来源：
TETRAHEDRON LETTERS | 2020年 / 61卷 / 07期
基金：
中国国家自然科学基金;
关键词：
Lactam; Radical reaction; Alkene difunctionalization; Trifluoromethyl; ASYMMETRIC-SYNTHESIS; RADICAL CYCLIZATION; EFFICIENT SYNTHESIS; CONCISE; DERIVATIVES; PROGRESS; ALKENES; SYSTEMS; AMIDES; ARENE;
D O I：
10.1016/j.tetlet.2019.151479
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient approach for the synthesis of gamma-lactams through radical-mediated trifluoromethylative aminocarbonylation of unactivated olefins is described. The transformation is initiated by the addition of an external CF3 radical to alkene followed by interception with intramolecular cyanamide. This protocol provides a useful method to furnish the synthetically valuable CF3-functionalized gamma-lactams. (C) 2019 Elsevier Ltd. All rights reserved.
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页数：3
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