An efficient palladium-catalyzed Negishi cross-coupling reaction with arylvinyl iodides:: facile regioselective synthesis of E-stilbenes and their analogues

被引：16

作者：

Kabir, M. Shahjahan

Monte, Aaron

Cook, James M. ^{[1
]}

机构：

[1] Univ Wisconsin, Dept Chem & Biochem, Milwaukee, WI 53201 USA

[2] Univ Wisconsin, Dept Chem, La Crosse, WI 54601 USA

来源：

TETRAHEDRON LETTERS | 2007年 / 48卷 / 41期

关键词：

Negishi cross-coupfing; regioselective synthesis of E-stilbenes; arylvinyl iodides; metal-catalyzed one-pot synthesis;

D O I：

10.1016/j.tetlet.2007.08.047

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A general synthetic route for the Pd-catalyzed cross-coupling of an arylzinc reagent with arylvinyl iodides (Negishi crosscoupling) has been developed. The system permits efficient and selective preparation of E-stilbenes and their analogues. It also functions effectively at low levels of catalyst loading without the need for an additional ligand and tolerates a wide range of functional groups including heteroaromatic substrates. A systematic study of various parameters was performed and correlated with catalystsubstrate activity. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：7269 / 7273

页数：5