Fluoroglycoproteins: ready chemical site-selective incorporation of fluorosugars into proteins

被引：40
作者：
Boutureira, Omar [1 ]
D'Hooge, Francois [1 ]
Fernandez-Gonzalez, Marta [1 ]
Bernardes, Goncalo J. L. [1 ]
Sanchez-Navarro, Macarena [1 ]
Koeppe, Julia R. [1 ]
Davis, Benjamin G. [1 ]
机构：
[1] Univ Oxford, Dept Chem, Chem Res Lab, Oxford OX1 3TA, England
来源：
CHEMICAL COMMUNICATIONS | 2010年 / 46卷 / 43期
基金：
英国工程与自然科学研究理事会; 英国生物技术与生命科学研究理事会; 比尔及梅琳达.盖茨基金会;
关键词：
LECTIN-CHAPERONE CALRETICULIN; POSITRON-EMISSION-TOMOGRAPHY; VIRUS-LIKE PARTICLES; CLICK CHEMISTRY; TERMINAL ALKYNES; IN-VIVO; GLYCOSYLATION; GLYCOPROTEINS; PEPTIDES; PROBES;
D O I：
10.1039/c0cc01576h
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A tag-and-modify strategy allows the practical synthesis of homogenous fluorinated glyco-amino acids, peptides and proteins carrying a fluorine label in the sugar and allows access to first examples of directly radiolabelled ([(18)F]-glyco)proteins.
引用
收藏
页码：8142 / 8144
页数：3
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