CEP-1347/KT7515, a JNK pathway inhibitor, supports the in vitro survival of chick embryonic neurons

被引：46

作者：

Borasio, GD ^{[1
]}

Horstmann, S

Anneser, JMH

Neff, NT

Glicksman, MA

机构：

[1] Univ Munich, Klinikum Grosshadern, Neurol Klin, D-81366 Munchen, Germany

[2] Cephalon Inc, W Chester, PA USA

来源：

NEUROREPORT | 1998年 / 9卷 / 07期

关键词：

ciliary neurons; dorsal root ganglion neurons; motor neurons; neurodegenerative disease; neuronal apoptosis; signal transduction; sympathetic neurons; tissue culture;

D O I：

10.1097/00001756-199805110-00034

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

DEVELOPING neurons depend on target-derived trophic factors for survival in vivo and in vitro, which also decrease the activity of c-Jun N-terminal kinase (JNK). We have recently described a survival-promoting effect of inhibitors of cyclin-dependent kinases and JNK on chick peripheral embryonic neurons. Here, we report that the small trophic molecule CEP-1347/KT7515, which has been shown to inhibit the JNK signalling pathway, can promote long term-survival of cultured chick embryonic dorsal root ganglion, sympathetic, ciliary and motor neurons. Because of their pharmacological properties, small trophic molecules such as CEP1347/KT7515 might be of interest for the treatment of neurodegenerative disorders. (C) 1998 Rapid Science Ltd.

引用

页码：1435 / 1439

页数：5

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