Tartrate-resistant acid phosphatase as a biomarker of bone turnover in dog

被引：7

作者：

Sousa, C. P. ^{[1
,2
,3
]}

Nery, F. ^{[4
]}

Azevedo, J. T. ^{[5
]}

Viegas, C. A. ^{[1
,2
,3
]}

Gomes, M. E. ^{[2
,3
]}

Dias, I. R. ^{[1
,2
,3
]}

机构：

[1] UTAD, Dept Vet Sci, P-5001801 Vila Real, Portugal

[2] DEP UM, 3Bs Res Grp Biomat Biodegradables & Biomimet, Guimaraes, Portugal

[3] PT Gov Assoc Lab, Inst Biotechnol & Bioengn, Braga, Portugal

[4] Lab Clin Pathol Pioledo SA, Vila Real, Portugal

[5] UTAD, Dept Anim Sci, CECAV, Vila Real, Portugal

来源：

ARQUIVO BRASILEIRO DE MEDICINA VETERINARIA E ZOOTECNIA | 2011年 / 63卷 / 01期

关键词：

dog; bone metabolism; bone resorption; osteoclast; BIOCHEMICAL MARKERS; SERUM; FRACTURE; METABOLISM; 5B;

D O I：

10.1590/S0102-09352011000100007

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

Values of serum tartrate-resistant acid phosphatase (TRAP) activity were obtained in adult dogs and its biological variability was assessed. Nine healthy skeletally mature Portuguese Podengo dogs were used for the determination of TRAP, total and bone alkaline phosphatase serum activities, and also to study their relationship with serum minerals, namely calcium (Ca), phosphorous (P), and magnesium (Mg). The serum TRAP activity was 2.19 +/- 0.56IU/mL, with intra-individual variation of 18.3% and inter-individual variation of 25.6%. Significant correlations were observed between serum TRAP activity and Ca (r=-0.3431; P<0.05), Ca and Mg (r=-0.787; P<0.01), and TRAP and Mg (r=0.397; P<0.05). The results indicate that serum TRAP activity in dog could be of great value in research and in clinical practice, providing complementary non-invasive information on bone metabolism.

引用

页码：40 / 45

页数：6

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