The cancer stem-cell signaling network and resistance to therapy

被引：126
作者：
Carnero, A. [1 ]
Garcia-Mayea, Y. [2 ]
Mir, C. [2 ]
Lorente, J. [2 ]
Rubio, I. T. [3 ]
LLeonart, M. E. [2 ]
机构：
[1] Univ Seville, Oncohematol & Genet Dept, Mol Biol Canc Grp, Inst Biomed Sevilla,IBIS,HUVR,CSIC, Campus HUVR,Edificio IBIS,Avda Manuel Siurot S-N, Seville 41013, Spain
[2] Hosp Valle De Hebron, Vall dHebron Inst Recerca VHIR, Translat Res Canc Stem Cell Grp, Dept Pathol, Pg Vall dHebron 119-129, Barcelona 08035, Spain
[3] Hosp Valle De Hebron, Vall dHebron Inst Oncol VHIO, Breast Surg Oncol Unit, Breast Canc Ctr, Pg Vall dHebron 119-129, Barcelona 08035, Spain
来源：
CANCER TREATMENT REVIEWS | 2016年 / 49卷
关键词：
Cancer; Conventional therapy; CSC; Metastasis; Oxidative stress; Stem cell therapy; GAMMA-SECRETASE INHIBITOR; ADVANCED SOLID TUMORS; CHRONIC LYMPHOCYTIC-LEUKEMIA; ACUTE MYELOID-LEUKEMIA; BREAST-CANCER; INITIATING CELLS; GASTRIC-CANCER; IN-VITRO; PHASE-I; GLYCOLYTIC-ENZYMES;
D O I：
10.1016/j.ctrv.2016.07.001
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The study of cancer stem cells (CSCs) has shown that tumors are driven by a subpopulation of self renewing CSCs that retain the capacity to engender the various differentiated cell populations that form tumors. The characterization of CSCs has indicated that CSCs are remarkably resistant to conventional radio- and chemo-therapy. Clinically, the remaining populations of CSC are responsible for metastasis and recurrence in patients with cancer, which can lead to the disease becoming chronic and incurable. Therefore, the elimination of CSCs is an important goal of cancer treatments. Furthermore, CSCs are subject to strong regulation by the surrounding microenvironment, which also impacts tumor responses. In this review, we discuss the mechanisms by which pathways that are defective in CSCs influence ultimately therapeutic and clinical outcomes. (C) 2016 Elsevier Ltd. All rights reserved.
引用
收藏
页码：25 / 36
页数：12
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