Precision medicine in type 1 diabetes

被引：29

作者：

Carr, Alice L. J. ^{[1
]}

Evans-Molina, Carmella ^{[2
,3
,4
,5
,6
,7
,8
]}

Oram, Richard A. ^{[1
]}

机构：

[1] Univ Exeter, Inst Biomed & Clin Sci, Med Sch, Exeter, Devon, England

[2] Indiana Univ Sch Med, Dept Pediat, Indianapolis, IN 46202 USA

[3] Indiana Univ Sch Med, Dept Med, Indianapolis, IN 46202 USA

[4] Indiana Univ Sch Med, Dept Anat Cell Biol & Physiol, Indianapolis, IN 46202 USA

[5] Indiana Univ Sch Med, Dept Biochem & Mol Biol, Indianapolis, IN 46202 USA

[6] Indiana Univ Sch Med, Ctr Diabet & Metab Dis, Indianapolis, IN 46202 USA

[7] Indiana Univ Sch Med, Herman B Wells Ctr Pediat Res, Indianapolis, IN 46202 USA

[8] Richard L Roudebush VA Med Ctr, Indianapolis, IN USA

来源：

DIABETOLOGIA | 2022年 / 65卷 / 11期

关键词：

Continuous glucose monitoring; C-peptide; Genetics; Insulin; Personalised medicine; Precision medicine; Review; Type; 1; diabetes; LOOP INSULIN DELIVERY; BETA-CELL FUNCTION; GENETIC RISK SCORE; C-PEPTIDE LEVELS; YOUNG-PEOPLE; ISLET AUTOANTIBODIES; CLINICAL UTILITY; GLYCEMIC CONTROL; PUMP THERAPY; CHILDREN;

D O I：

10.1007/s00125-022-05778-3

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

First envisioned by early diabetes clinicians, a person-centred approach to care was an aspirational goal that aimed to match insulin therapy to each individual's unique requirements. In the 100 years since the discovery of insulin, this goal has evolved to include personalised approaches to type 1 diabetes diagnosis, treatment, prevention and prediction. These advances have been facilitated by the recognition of type 1 diabetes as an autoimmune disease and by advances in our understanding of diabetes pathophysiology, genetics and natural history, which have occurred in parallel with advancements in insulin delivery, glucose monitoring and tools for self-management. In this review, we discuss how these personalised approaches have improved diabetes care and how improved understanding of pathogenesis and human biology might inform precision medicine in the future.

引用

页码：1854 / 1866

页数：13

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