Nickel-Catalyzed Enantioselective C-C Bond Formation through Csp2-O Cleavage in Aryl Esters

被引：88

作者：

Cornella, Josep ^{[1
]}

Jackson, Evan P. ^{[1
]}

Martin, Ruben ^{[1
,2
]}

机构：

[1] Inst Chem Res Catalonia ICIQ, Tarragona 43007, Spain

[2] Catalan Inst Res & Adv Studies ICREA, Barcelona 08010, Spain

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2015年 / 54卷 / 13期

基金：

欧洲研究理事会;

关键词：

aryl esters; C-O cleavage; C-O electrophiles; nickel catalysis; CROSS-COUPLING REACTIONS; ALPHA-ARYLATION; O BOND; REDUCTIVE CLEAVAGE; ACTIVATION; CONSTRUCTION; PALLADIUM; ELECTROPHILES; STRATEGY; KETONES;

D O I：

10.1002/anie.201412051

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We report the first enantioselective C-C bond formation through C-O bond cleavage using aryl ester counterparts. This method is characterized by its wide substrate scope and results in the formation of quaternary stereogenic centers with high yields and asymmetric induction.

引用

页码：4075 / 4078

页数：4

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