Potential of immunotherapy for hepatocellular carcinoma

被引：105
作者：
Breous, Ekaterina [1 ]
Thimme, Robert [1 ]
机构：
[1] Univ Freiburg, Dept Med 2, D-79106 Freiburg, Germany
来源：
JOURNAL OF HEPATOLOGY | 2011年 / 54卷 / 04期
关键词：
Hepatocellular carcinoma (HCC); Tumour antigens; T cell responses; Immune suppressor mechanisms; Immunotherapy; T-CELL RESPONSES; HUMAN ALPHA-FETOPROTEIN; DENDRITIC CELLS; COSTIMULATORY MOLECULES; ADOPTIVE IMMUNOTHERAPY; CLASS-I; EXPRESSION; PEPTIDES; RECURRENCE; INFILTRATE;
D O I：
10.1016/j.jhep.2010.10.013
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide with limited therapeutic options. Since HCC has been shown to be immunogenic, T cell-based immunotherapy is considered a promising treatment. In this review, we summarize current knowledge of T cell responses against tumour-associated antigens, as well as the mechanisms underlying the poor quality of these responses in patients with HCC. Insights into these important aspects of HCC immunology are crucial for the further development of novel immunotherapies. (C) 2010 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码：830 / 834
页数：5
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