Receptor tyrosine kinase-G-protein coupled receptor complex signaling in mammalian cells

被引：23

作者：

Pyne, Nigel J. ^{[1
]}

Waters, Catherine M. ^{[1
]}

Long, Jaclyn S. ^{[1
]}

Moughal, Noreen A. ^{[1
]}

Tigyi, Gabor ^{[1
]}

Pyne, Susan ^{[1
]}

机构：

[1] Univ Strathclyde, Strathclyde Inst Biomed Sci, Dept Physiol & Pharmacol, 27 Taylor St, Glasgow G4 0NR, Lanark, Scotland

来源：

ADVANCES IN ENZYME REGULATION, VOL 47 | 2007年 / 47卷

基金：

英国生物技术与生命科学研究理事会;

关键词：

D O I：

10.1016/j.advenzreg.2006.12.011

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We describe here formation of a novel functional signaling complex between RTK and GPCRπ. This permits the use of activated G-protein subunits by the RTK in response to growth factor and that are made available by the constitutive activity of the GPCR or by binding of ligand to the latter. Moreover, β-arrestin associates with the receptor complex and participates in growth factor-dependent recruitment of c-Src, whereupon the kinase is activated by Gβγ subunits. This enables signal relay to down-stream effectors such as p42/p44 mitogen-activated protein kinases. The novel RTK-GPCR complex is involved in regulating important cellular responses, such as growth and cell migration, and dysfunction of this complex might play a significant role in hyperplasic disease states. © 2007 Elsevier Ltd. All rights reserved.

引用

页码：271 / +

页数：3

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