C-H•••O and other weak hydrogen bonds.: From crystal engineering to virtual screening

被引：520

作者：

Desiraju, GR ^{[1
]}

机构：

[1] Univ Hyderabad, Sch Chem, Hyderabad 500046, Andhra Pradesh, India

来源：

CHEMICAL COMMUNICATIONS | 2005年 / 24期

关键词：

D O I：

10.1039/b504372g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Hydrogen bonds, X - H(...)A, formed by weak donors (X = C) and acceptors (A = pi system) were generally dismissed as being of little consequence before and even during the 1970s. This situation changed in the early 1980s, and during the two following decades they were implicated as being significant in many small molecule crystal structures, and also in solution. Today, knowledge gained about these interactions is being used to understand the structure of biomolecules with implications for structure based drug design.

引用

页码：2995 / 3001

页数：7

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