Kidney disease associated with plasma cell dyscrasias

被引：42

作者：

Heher, Eliot C. ^{[1
]}

Goes, Nelson B. ^{[1
]}

Spitzer, Thomas R. ^{[2
]}

Raje, Noopur S. ^{[2
]}

Humphreys, Benjamin D. ^{[3
]}

Anderson, Kenneth C. ^{[4
]}

Richardson, Paul G. ^{[4
]}

机构：

[1] Massachusetts Gen Hosp, Div Nephrol, Boston, MA 02114 USA

[2] Massachusetts Gen Hosp, Div Hematol & Oncol, Boston, MA 02114 USA

[3] Brigham & Womens Hosp, Div Nephrol, Boston, MA 02115 USA

[4] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA

来源：

BLOOD | 2010年 / 116卷 / 09期

关键词：

IMMUNOGLOBULIN LIGHT-CHAINS; PRIMARY SYSTEMIC AMYLOIDOSIS; REFRACTORY MULTIPLE-MYELOMA; HIGH-DOSE DEXAMETHASONE; ACUTE-RENAL-FAILURE; MONOCLONAL GAMMOPATHY; DEPOSITION DISEASE; CAST NEPHROPATHY; BONE-MARROW; BORTEZOMIB;

D O I：

10.1182/blood-2010-03-258608

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Plasma cell dyscrasias are frequently encountered malignancies often associated with kidney disease through the production of monoclonal immunoglobulin (Ig). Paraproteins can cause a remarkably diverse set of pathologic patterns in the kidney and recent progress has been made in explaining the molecular mechanisms of paraprotein-mediated kidney injury. Other recent advances in the field include the introduction of an assay for free light chains and the use of novel antiplasma cell agents that can reverse renal failure in some cases. The role of stem cell transplantation, plasma exchange, and kidney transplantation in the management of patients with paraprotein-related kidney disease continues to evolve. (Blood. 2010;116(9):1397-1404)

引用

页码：1397 / 1404

页数：8

共 93 条

[11] Plasma exchange when myeloma presents as acute renal failure - A randomized, controlled trial [J].

Clark, WF ;

Stewart, AK ;

Rock, GA ;

Sternbach, M ;

Sutton, DM ;

Barrett, BL ;

Heidenheim, AP ;

Garg, AX ;

Churchill, DN .

ANNALS OF INTERNAL MEDICINE, 2005, 143 (11) :777-784

[12] Light-chain removal by plasmapheresis in myeloma-associated renal failure [J].

Cserti, Christine ;

Haspel, Richard ;

Stowell, Christopher ;

Dzik, Walter .

TRANSFUSION, 2007, 47 (03) :511-514

[13] Risk of antigen excess in serum free light chain measurements [J].

Daval, Sandrine ;

Tridon, Arlette ;

Mazeron, Nicole ;

Ristori, Jean-Michel ;

Evrard, Bertrand .

CLINICAL CHEMISTRY, 2007, 53 (11) :1985-1986

[14]

Dieterle F, 2008, CURR OPIN DRUG DISC, V11, P60

[15] Treatment of plasma cell dyscrasias with lenalidomide [J].

Dimopoulos, M. A. ;

Kastritis, E. ;

Rajkumar, S. V. .

LEUKEMIA, 2008, 22 (07) :1343-1353

[16]

DREWINKO B, 1981, BLOOD, V57, P333

[17]

Eriksson T, 2003, J PHARM PHARMACOL, V55, P1701, DOI 10.1211/0022357022241

[18] Myeloma responses and tolerance following combined kidney and nonmyeloablative marrow transplantation:: In vivo and in vitro analyses [J].

Fudaba, Y. ;

Spitzer, T. R. ;

Shaffer, J. ;

Kawai, T. ;

Fehr, T. ;

Delmonico, F. ;

Preffer, F. ;

Tolkoff-Rubin, N. ;

Dey, B. R. ;

Saidman, S. L. ;

Kraus, A. ;

Bonnefoix, T. ;

McAfee, S. ;

Power, K. ;

Kattleman, K. ;

Colvin, R. B. ;

Sachs, D. H. ;

Cosimi, A. B. ;

Sykes, M. .

AMERICAN JOURNAL OF TRANSPLANTATION, 2006, 6 (09) :2121-2133

[19]

Gu X, 2006, ARCH PATHOL LAB MED, V130, P165

[20] Autologous Hematopoietic Stem-Cell Transplantation for Multiple Myeloma [J].

Harousseau, Jean-Luc ;

Moreau, Philippe .

NEW ENGLAND JOURNAL OF MEDICINE, 2009, 360 (25) :2645-2654

← 1 2 3 4 5 6 7 8 9 10 →