Expression of caveolin-1 in gastrointestinal and extraintestinal cancers

被引：15

作者：

Juhász, M

Chen, J

Tulassay, Z

Malfertheiner, P

Ebert, MPA

机构：

[1] Otto von Guericke Univ, Dept Gastroenterol Hepatol & Infect Dis, D-39120 Magdeburg, Germany

[2] Semmelweis Univ, Fac Med, Dept Med 2, H-1088 Budapest, Hungary

来源：

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY | 2003年 / 129卷 / 09期

关键词：

caveolin-1; gastrointestinal cancer; extraintestinal cancer; tumor-suppressor gene;

D O I：

10.1007/s00432-003-0468-0

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Caveolae are uniform vesicular invaginations of the cell membrane. Caveolin-1 is responsible for the formation of caveolae and plays a key role in membrane traffic and signal transduction. The contribution of caveolin-1 to carcinogenesis has been widely investigated; however, the expression pattern of caveolin-1 is controversial both in gastrointestinal and extraintestinal cancers. Most of the results based on cancer cell line experiments suggest that caveolin-1 might act as a tumor-suppressor gene. On the contrary, several studies on the expression of caveolin-1 in tumor tissues indicate a possible tumor-promoting effect of caveolin-1. In this article we summarize the divergent results of caveolin-1 expression in gastrointestinal and extraintestinal cancer regarding possible future therapeutic implications.

引用

页码：493 / 497

页数：5

共 42 条

[1]

Bender FC, 2000, CANCER RES, V60, P5870

[2] Gene expression profiling of human colon cancer cells following inhibition of signal transduction by 17-allylamino-17-demethoxygeldanamycin, an inhibitor of hsp90 molecular chaperone [J].