Sir2 flexes its muscle

被引:5
|
作者
Bedalov, A
Simon, JA
机构
[1] Fred Hutchinson Canc Res Ctr, Div Clin Res, Seattle, WA 98107 USA
[2] Fred Hutchinson Canc Res Ctr, Human Biol Div, Seattle, WA 98107 USA
关键词
D O I
10.1016/S1534-5807(03)00237-5
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
A new report reveals a role for the mammalian NAD-dependent deacetylase Sir2 in repressing the muscle cell differentiation program and implicates the cellular redox state as a critical determinant of transcriptional activity of differentiation-specific genes.
引用
收藏
页码:188 / 189
页数:2
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