Sir2 flexes its muscle

被引：5

作者：

Bedalov, A

Simon, JA

机构：

[1] Fred Hutchinson Canc Res Ctr, Div Clin Res, Seattle, WA 98107 USA

[2] Fred Hutchinson Canc Res Ctr, Human Biol Div, Seattle, WA 98107 USA

来源：

DEVELOPMENTAL CELL | 2003年 / 5卷 / 02期

关键词：

D O I：

10.1016/S1534-5807(03)00237-5

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

A new report reveals a role for the mammalian NAD-dependent deacetylase Sir2 in repressing the muscle cell differentiation program and implicates the cellular redox state as a critical determinant of transcriptional activity of differentiation-specific genes.

引用

页码：188 / 189

页数：2

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